Complex ancient genetic structure and cultural transitions in Southern African populations

Vincenzo Lorenzo Pascali, Francesco Montinaro, Cristian Capelli, George B. J. Busby, Miguel Gonzalez-Santos, Ockie Oosthuitzen, Erika Oosthuitzen, Paolo Anagnostou, Giovanni Destro-Bisol

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The characterization of the structure of southern African populations has been the subject of numerous genetic, medical, linguistic, archaeological, and anthropological investigations. Current diversity in the subcontinent is the result of complex events of genetic admixture and cultural contact between early inhabitants and migrants that arrived in the region over the last 2000 years. Here, we analyze 1856 individuals from 91 populations, comprising novel and published genotype data, to characterize the genetic ancestry profiles of 631 individuals from 51 southern African populations. Combining both local ancestry and allele frequency based analyses, we identify a tripartite, ancient, Khoesan-related genetic structure. This structure correlates neither with linguistic affiliation nor subsistence strategy, but with geography, revealing the importance of isolation-by-distance dynamics in the area. Fine-mapping of these components in southern African populations reveals admixture and cultural reversion involving several Khoesan groups, and highlights that Bantu speakers and Coloured individuals have different mixtures of these ancient ancestries.
Original languageEnglish
Pages (from-to)303-316
Number of pages14
JournalGenetics
Volume205
DOIs
Publication statusPublished - 2017

Keywords

  • African prehistory
  • Ancient structure
  • Genetics
  • Khoesan
  • Sub-Saharan Africa

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