Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

Maria Teresa Voso, T Ottone, L Cicconi, Sk Hasan, S Lavorgna, M Divona, E Montefusco, L Melillo, E Barragán, U Platzbecker, L Giannì, M Hubmann, M Pagoni, S Amadori, F. Lo Coco

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10 Citations (Scopus)

Abstract

Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.
Original languageEnglish
Pages (from-to)474-478
Number of pages5
JournalLeukemia Research
Volume36
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Aged
  • Antineoplastic Agents
  • Child
  • DNA (Cytosine-5-)-Methyltransferase
  • DNA Mutational Analysis
  • DNA-Binding Proteins
  • Female
  • Humans
  • Isocitrate Dehydrogenase
  • Leukemia, Promyelocytic, Acute
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins
  • Radiotherapy
  • Young Adult
  • fms-Like Tyrosine Kinase 3

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