Colon cancer stem cells: controversies and perspectives

Wanda Lattanzi, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Maria Ausiliatrice Puglisi, Valentina Tesori

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Tumors have long been viewed as a population in which all cells have the equal propensity to form new tumors, the so called conventional stochastic model. The cutting-edge theory on tumor origin and progression, tends to consider cancer as a stem cell disease. Stem cells are actively involved in the onset and maintenance of colon cancer. This review is intended to examine the state of the art on colon cancer stem cells (CSCs), with regard to the recent achievements of basic research and to the corresponding translational consequences. Specific prominence is given to the hypothesized origin of CSCs and to the methods for their identification. The growing understanding of CSC biology is driving the optimization of novel anti-cancer targeted drugs.
Original languageEnglish
Pages (from-to)2997-3006
Number of pages10
JournalWORLD JOURNAL OF GASTROENTEROLOGY
Volume19
DOIs
Publication statusPublished - 2013

Keywords

  • Animals
  • Antineoplastic Agents
  • CD133
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Cell Transformation, Neoplastic
  • Chemoresistance
  • Colon cancer stem cells
  • Colonic Neoplasms
  • Colorectal cancer
  • Humans
  • Molecular Targeted Therapy
  • Neoplastic Stem Cells
  • Signal Transduction
  • Therapy
  • Tumor Markers, Biological

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