Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study

Laura Serra; Massimo Musicco; Mara Cercignani; Mario Torso; Barbara Spanò; Chiara Mastropasqua; Giovanni Giulietti; Camillo Marra; Giuseppe Bruno; Giacomo Koch; Carlo Caltagirone; Marco Bozzali

doi:10.1016/j.neurobiolaging.2014.10.010

Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study

Laura Serra, Massimo Musicco, Mara Cercignani, Mario Torso, Barbara Spanò, Chiara Mastropasqua, Giovanni Giulietti, Camillo Marra, Giuseppe Bruno, Giacomo Koch, Carlo Caltagirone, Marco Bozzali

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Neurobiology of Aging
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.10.010
Publication status	Published - 2014

Keywords

AD
Cognitive reserve
MTA
Relative risk
White matter lesions
a-MCI

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10.1016/j.neurobiolaging.2014.10.010

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title = "Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study",

abstract = "This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.",

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doi = "10.1016/j.neurobiolaging.2014.10.010",

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T1 - Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study

AU - Serra, Laura

AU - Musicco, Massimo

AU - Cercignani, Mara

AU - Torso, Mario

AU - Spanò, Barbara

AU - Mastropasqua, Chiara

AU - Giulietti, Giovanni

AU - Marra, Camillo

AU - Bruno, Giuseppe

AU - Koch, Giacomo

AU - Caltagirone, Carlo

AU - Bozzali, Marco

PY - 2014

Y1 - 2014

N2 - This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.

AB - This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.

KW - AD

KW - Cognitive reserve

KW - MTA

KW - Relative risk

KW - White matter lesions

KW - a-MCI

KW - AD

KW - Cognitive reserve

KW - MTA

KW - Relative risk

KW - White matter lesions

KW - a-MCI

UR - http://hdl.handle.net/10807/61154

U2 - 10.1016/j.neurobiolaging.2014.10.010

DO - 10.1016/j.neurobiolaging.2014.10.010

M3 - Article

SN - 0197-4580

SP - N/A-N/A

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study

Abstract

Keywords

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