Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study.

Andrea Silvestrini, Elisabetta Meucci, Elena Teresa Carmela Giacchi Mancini, Sebastiano Raimondo, Antonio Mancini, R. Festa, L. Tiano, G. P. Littarru

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplementation with coenzyme Q10 , 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q10 100 mg per die. Seminal plasma antioxidant capacity was measured using a spectroscopic method. Coenzyme Q10 therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy.
Original languageEnglish
Pages (from-to)805-807
Number of pages3
JournalANDROLOGIA
Publication statusPublished - 2014

Keywords

  • oxidative stress

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