Clusters of cognitive and behavioral disorders clearly distinguish primary progressive aphasia from frontal lobe dementia, and Alzheimer's disease

Camillo Marra, Carlo Masullo, Antonio Daniele, Sandro Misciagna, Alessandra Bizzarro, S. Misciagna

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background/Aims: Frontal lobe dementia (FLD) and primary nonfluent progressive aphasia (PnPA) are two forms of frontotemporal lobe degeneration. The relationship between these conditions remains unclear. Our study aimed to better define the behavioral and cognitive clusters characterizing PnPA patients. Methods: We cognitively and behaviorally evaluated three groups of newly diagnosed patients affected by Alzheimer's disease (AD, n = 20), FLD (n = 22) and PnPA (n = 10), in order to assess the cognitive-behavioral pattern of PnPA, compared to both FLD and AD. Results: We found, as expected, worse performances in episodic memory in AD, of both the verbal fluency and naming tasks in PnPA, while FLD mainly showed behavioral disorders associated with an unremarkable deficit in the executive tasks. PnPA was not characterized by any significant behavioral disorders. Factor analysis-extracted three main factors ('mnesic', 'behavioral' and 'linguistic') clearly correlated to each group. A discriminant analysis based on the extracted factors correctly classified 84.6% of all patients. Conclusion: The evidence of a characteristics cognitive profile, without any significant behavioral changes, highlights that PnPA is different from other forms of frontotemporal lobe degeneration regarding both the cognitive and behavioral patterns; thus, it should be considered independently in further studies. Copyright © 2007 S. Karger AG.
Original languageEnglish
Pages (from-to)317-326
Number of pages10
JournalDementia and Geriatric Cognitive Disorders
Volume24
DOIs
Publication statusPublished - 2007

Keywords

  • Aged
  • Alzheimer Disease
  • Analysis of Variance
  • Aphasia, Primary Progressive
  • Atrophy
  • Behavioral psychiatric symptoms of dementia
  • Cognition Disorders
  • Dementia
  • Diagnosis, Differential
  • Factor Analysis, Statistical
  • Frontal Lobe
  • Frontotemporal dementia
  • Humans
  • Memory Disorders
  • Mental Disorders
  • Middle Aged
  • Neuropsychological Tests
  • Neuropsychological assessment
  • Problem Solving
  • Progressive aphasia
  • Semantics
  • Single-Blind Method
  • Temporal Lobe
  • Verbal Behavior

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