Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

Andrea Silvestrini; Carmine Bruno; Edoardo Vergani; Angela Venuti; Angela Maria Rita Favuzzi; Francesco Guidi; Nicola Nicolotti; Elisabetta Meucci Calabrese; Alvaro Mordente; Antonio Mancini

doi:10.1371/journal.pone.0210320

Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

Andrea Silvestrini^*, Carmine Bruno, Edoardo Vergani, Angela Venuti, Angela Maria Rita Favuzzi, Francesco Guidi, Nicola Nicolotti, Elisabetta Meucci Calabrese, Alvaro Mordente, Antonio Mancini^*

^*Corresponding author

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	PLoS One
DOIs	https://doi.org/10.1371/journal.pone.0210320
Publication status	Published - 2019

Keywords

oxidative stress, heart failure

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0210320

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title = "Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study",

abstract = "Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.",

keywords = "oxidative stress, heart failure, oxidative stress, heart failure",

author = "Andrea Silvestrini and Carmine Bruno and Edoardo Vergani and Angela Venuti and Favuzzi, {Angela Maria Rita} and Francesco Guidi and Nicola Nicolotti and {Meucci Calabrese}, Elisabetta and Alvaro Mordente and Antonio Mancini",

year = "2019",

doi = "10.1371/journal.pone.0210320",

language = "English",

pages = "1--7",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

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TY - JOUR

T1 - Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

AU - Silvestrini, Andrea

AU - Bruno, Carmine

AU - Vergani, Edoardo

AU - Venuti, Angela

AU - Favuzzi, Angela Maria Rita

AU - Guidi, Francesco

AU - Nicolotti, Nicola

AU - Meucci Calabrese, Elisabetta

AU - Mordente, Alvaro

AU - Mancini, Antonio

PY - 2019

Y1 - 2019

N2 - Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.

AB - Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.

KW - oxidative stress, heart failure

UR - http://hdl.handle.net/10807/129120

U2 - 10.1371/journal.pone.0210320

DO - 10.1371/journal.pone.0210320

M3 - Article

SN - 1932-6203

SP - 1

EP - 7

JO - PLoS One

JF - PLoS One

ER -

Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

Abstract

Keywords

UN SDGs

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