Circulating CD8+CD56-Perforin+ T cells are increased in Multiple Sclerosis patients

Giovanni Frisullo, Domenico Plantone, Alessandro Marti, Raffaele Iorio, Viviana Nociti, Agata Katia Patanella, Anna Paola Batocchi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalJournal of Neuroimmunology
Volume2011
Publication statusPublished - 2011

Keywords

  • multiple sclerosis

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