Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study

Maria Gabriella Ferrandina; Maria Antonietta Gambacorta; Valerio Gallotta; Daniela Smaniotto; Anna Fagotti; Luca Tagliaferri; Elvira Foti; Francesco Fanfani; Rosa Autorino; Giovanni Scambia; Vincenzo Valentini

doi:10.1016/j.ijrobp.2014.07.033

Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study

Maria Gabriella Ferrandina
, Maria Antonietta Gambacorta
, Valerio Gallotta
, Daniela Smaniotto
, Anna Fagotti
, Luca Tagliaferri
, Elvira Foti
, Francesco Fanfani
, Rosa Autorino
, Giovanni Scambia
, Vincenzo Valentini

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

This prospective, phase 2 study aimed at assessing the efficacy of accelerated fractionation radiation therapy by concomitant boosts (CBs) associated with chemoradiation therapy (CRT) of the whole pelvis, in improving the rate of pathological complete response (pCR) to treatment in patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IB2-IVA locally advanced cervical cancer.

Original language	English
Pages (from-to)	778-785
Number of pages	8
Journal	International Journal of Radiation Oncology Biology Physics
Volume	90
DOIs	https://doi.org/10.1016/j.ijrobp.2014.07.033
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adenocarcinoma
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Squamous Cell
Chemoradiotherapy, Adjuvant
Cisplatin
Deoxycytidine
Dose Fractionation
Drug Administration Schedule
Female
Fluorouracil
Humans
Hysterectomy
Lymph Node Excision
Middle Aged
Pelvis
Prospective Studies
Radiotherapy, Conformal
Survival
Uterine Cervical Neoplasms

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10.1016/j.ijrobp.2014.07.033

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Ferrandina, M. G., Gambacorta, M. A., Gallotta, V., Smaniotto, D., Fagotti, A., Tagliaferri, L., Foti, E., Fanfani, F., Autorino, R., Scambia, G., & Valentini, V. (2014). Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study. International Journal of Radiation Oncology Biology Physics, 90, 778-785. https://doi.org/10.1016/j.ijrobp.2014.07.033

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title = "Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study",

abstract = "This prospective, phase 2 study aimed at assessing the efficacy of accelerated fractionation radiation therapy by concomitant boosts (CBs) associated with chemoradiation therapy (CRT) of the whole pelvis, in improving the rate of pathological complete response (pCR) to treatment in patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IB2-IVA locally advanced cervical cancer.",

keywords = "Adenocarcinoma, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Chemoradiotherapy, Adjuvant, Cisplatin, Deoxycytidine, Dose Fractionation, Drug Administration Schedule, Female, Fluorouracil, Humans, Hysterectomy, Lymph Node Excision, Middle Aged, Pelvis, Prospective Studies, Radiotherapy, Conformal, Survival, Uterine Cervical Neoplasms, Adenocarcinoma, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Chemoradiotherapy, Adjuvant, Cisplatin, Deoxycytidine, Dose Fractionation, Drug Administration Schedule, Female, Fluorouracil, Humans, Hysterectomy, Lymph Node Excision, Middle Aged, Pelvis, Prospective Studies, Radiotherapy, Conformal, Survival, Uterine Cervical Neoplasms",

author = "Ferrandina, \{Maria Gabriella\} and Gambacorta, \{Maria Antonietta\} and Valerio Gallotta and Daniela Smaniotto and Anna Fagotti and Luca Tagliaferri and Elvira Foti and Francesco Fanfani and Rosa Autorino and Giovanni Scambia and Vincenzo Valentini",

year = "2014",

doi = "10.1016/j.ijrobp.2014.07.033",

language = "English",

volume = "90",

pages = "778--785",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

}

Ferrandina, MG, Gambacorta, MA, Gallotta, V, Smaniotto, D, Fagotti, A , Tagliaferri, L, Foti, E, Fanfani, F, Autorino, R, Scambia, G & Valentini, V 2014, 'Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study', International Journal of Radiation Oncology Biology Physics, vol. 90, pp. 778-785. https://doi.org/10.1016/j.ijrobp.2014.07.033

Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study. / Ferrandina, Maria Gabriella; Gambacorta, Maria Antonietta; Gallotta, Valerio et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 90, 2014, p. 778-785.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study

AU - Ferrandina, Maria Gabriella

AU - Gambacorta, Maria Antonietta

AU - Gallotta, Valerio

AU - Smaniotto, Daniela

AU - Fagotti, Anna

AU - Tagliaferri, Luca

AU - Foti, Elvira

AU - Fanfani, Francesco

AU - Autorino, Rosa

AU - Scambia, Giovanni

AU - Valentini, Vincenzo

PY - 2014

Y1 - 2014

N2 - This prospective, phase 2 study aimed at assessing the efficacy of accelerated fractionation radiation therapy by concomitant boosts (CBs) associated with chemoradiation therapy (CRT) of the whole pelvis, in improving the rate of pathological complete response (pCR) to treatment in patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IB2-IVA locally advanced cervical cancer.

AB - This prospective, phase 2 study aimed at assessing the efficacy of accelerated fractionation radiation therapy by concomitant boosts (CBs) associated with chemoradiation therapy (CRT) of the whole pelvis, in improving the rate of pathological complete response (pCR) to treatment in patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IB2-IVA locally advanced cervical cancer.

KW - Adenocarcinoma

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Carcinoma, Squamous Cell

KW - Chemoradiotherapy, Adjuvant

KW - Cisplatin

KW - Deoxycytidine

KW - Dose Fractionation

KW - Drug Administration Schedule

KW - Female

KW - Fluorouracil

KW - Humans

KW - Hysterectomy

KW - Lymph Node Excision

KW - Middle Aged

KW - Pelvis

KW - Prospective Studies

KW - Radiotherapy, Conformal

KW - Survival

KW - Uterine Cervical Neoplasms

KW - Adenocarcinoma

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Carcinoma, Squamous Cell

KW - Chemoradiotherapy, Adjuvant

KW - Cisplatin

KW - Deoxycytidine

KW - Dose Fractionation

KW - Drug Administration Schedule

KW - Female

KW - Fluorouracil

KW - Humans

KW - Hysterectomy

KW - Lymph Node Excision

KW - Middle Aged

KW - Pelvis

KW - Prospective Studies

KW - Radiotherapy, Conformal

KW - Survival

KW - Uterine Cervical Neoplasms

UR - http://hdl.handle.net/10807/66697

U2 - 10.1016/j.ijrobp.2014.07.033

DO - 10.1016/j.ijrobp.2014.07.033

M3 - Article

SN - 0360-3016

VL - 90

SP - 778

EP - 785

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

ER -

Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study

Abstract

UN SDGs

Keywords

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