Chemoradiation with concomitant boosts followed by radical surgery in locally advanced cervical cancer: long-term results of the ROMA-2 prospective phase 2 study

Maria Gabriella Ferrandina, Maria Antonietta Gambacorta, Anna Fagotti, Francesco Fanfani, Giovanni Scambia, Vincenzo Valentini, Valerio Gallotta, Daniela Smaniotto, Luca Tagliaferri, Elvira Foti, Rosa Autorino

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

This prospective, phase 2 study aimed at assessing the efficacy of accelerated fractionation radiation therapy by concomitant boosts (CBs) associated with chemoradiation therapy (CRT) of the whole pelvis, in improving the rate of pathological complete response (pCR) to treatment in patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IB2-IVA locally advanced cervical cancer.
Original languageEnglish
Pages (from-to)778-785
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume90
DOIs
Publication statusPublished - 2014

Keywords

  • Adenocarcinoma
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols
  • Carcinoma, Squamous Cell
  • Chemoradiotherapy, Adjuvant
  • Cisplatin
  • Deoxycytidine
  • Dose Fractionation
  • Drug Administration Schedule
  • Female
  • Fluorouracil
  • Humans
  • Hysterectomy
  • Lymph Node Excision
  • Middle Aged
  • Pelvis
  • Prospective Studies
  • Radiotherapy, Conformal
  • Survival
  • Uterine Cervical Neoplasms

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