Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinib

Simona Sica, M Breccia, R Latagliata, F Stagno, L Luciano, A Gozzini, F Castagnetti, C Fava, F Cavazzini, M Annunziata, A Russo Rossi, P Pregno, E Abruzzese, P Vigneri, G Rege Cambrin, F Pane, V Santini, G Specchia, G Rosti, G. Alimena

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Abstract

Comorbidities may affect survival and choice of treatment among cancer patients. In fact, comorbidities have been identified as significant determinants of response to therapy in older patients with acute myeloid leukemia, breast cancer, head and neck cancer, and lung cancer. The Charlson comorbidity index and adult comorbidity evaluation-27 are lists of comorbidities with a weight assigned from 1 to 6 for the former and from 0 to 3 for the latter score, derived from relative risk estimates of a proportional hazard regression model using clinical data.
Original languageEnglish
Pages (from-to)1457-1461
Number of pages5
JournalHaematologica
Volume96
DOIs
Publication statusPublished - 2011

Keywords

  • Aged
  • Antineoplastic Agents
  • Female
  • Humans
  • Incidence
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Male
  • Medication Adherence
  • Pleural Effusion
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Retrospective Studies
  • Thiazoles
  • Treatment Outcome

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