Characterization of salivary proteins of schizophrenic and bipolar disorder patients by top-down proteomics

Federica Iavarone, Massimo Cordaro, Massimo Castagnola, Tiziana Cabras, Marianna Melis, Giovanna Platania, Barbara Manconi, Raffaele Petruzzelli, Alberto Siracusano, Gavino Faa, Irene Messana, Marco Zanasi

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26 Citations (Scopus)


The analysis of whole saliva of 32 subjects with diagnosis of schizophrenia (SZ), 17 with diagnosis of bipolar disorder (BD), and 31 healthy subjects divided in non-smokers (HN; n=19) and smokers (HS; n=12) using an HPLC-ESI-MS top-down platform is reported in this study. Both SZ and BD revealed more than 10 fold mean increase of α-defensins 1-4, S100A12, cystatin A and S-derivatives of cystatin B levels with respect to the HN and HS control groups. No differences of protein levels were observed between SZ and BD groups and between HN and HS groups. Moreover, the correlation coefficients among the different proteins were significantly better in BD group than in SZ group. BIOLOGICAL SIGNIFICANCE: This study on whole saliva confirms a schizophrenia-associated dysregulation of immune pathway of peripheral white blood cells and suggests that the dysregulation of BD group could involve the activation of more specific cell type than that of SZ group.
Original languageEnglish
Pages (from-to)N/A-N/A
Publication statusPublished - 2014




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