Characterization of dendrimer properties by capillary electrophoresis and their use as pseudostationary phases

Elisabetta Meucci, Massimo Castagnola, Cecilia Zuppi, Diana Valeria Rossetti, Federica Vincenzoni, Alberto Vitali, Irene Messana, A. Lupi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The general properties of dendrimers and in particular their electrolytic characteristics that are relevant in electrokinetic separations, are described. In order to confirm theoretical considerations on commercial dendrimer charge and hydrodynamic radius, several capillary zone electrophoresis (CZE) experiments were performed. Electrophoretic mobilities measured at different pH values indicated a sensible increase of dendrimer hydrodynamic radius at pH values lower than 2.5. This was probably due to the Coulombic repulsion of charged amine groups of the inner dendrimer shells. The principal reasons that should address the use of dendrimers as pseudostationary phases in micellar electrokinetic chromatography (MEKC) are discussed. Moreover, a survey of different separations performed utilizing dendrimers in MEKC as well as of several future plausible uses of various classes of dendrimers is presented.
Original languageEnglish
Pages (from-to)1769-1778
Number of pages10
JournalElectrophoresis
Publication statusPublished - 2002

Keywords

  • capillare
  • dendrimeri
  • elettroforesi

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