Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

Luca Laurenti, Luciana De Luca, Giovanna Rosaria Mansueto, Idanna Innocenti, Giovanni D’Arena, Vittorio Simeon, Stefania Trino, Ilaria Laurenzana, Antonella Caivano, Francesco La Rocca, Oreste Villani, Giovanna Mansueto, Silvia Deaglio, Stefano Molica, Giuseppe Pietrantuono, Angelo De Stradis, Luigi Del Vecchio, Pellegrino Musto

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalLEUKEMIA & LYMPHOMA
Volume14
DOIs
Publication statusPublished - 2016

Keywords

  • Cancer Research
  • Chronic lymphocytic leukemia
  • Hematology
  • Oncology
  • flow cytometry
  • microvesicles
  • prognosis

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