Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

Luciana De Luca; Giovanni D’Arena; Vittorio Simeon; Stefania Trino; Ilaria Laurenzana; Antonella Caivano; Francesco La Rocca; Oreste Villani; Giovanna Mansueto; Giovanna Rosaria Mansueto; Silvia Deaglio; Idanna Innocenti; Luca Laurenti; Stefano Molica; Giuseppe Pietrantuono; Angelo De Stradis; Luigi Del Vecchio; Pellegrino Musto

doi:10.1080/10428194.2016.1243790

Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

Luciana De Luca, Giovanni D’Arena, Vittorio Simeon, Stefania Trino, Ilaria Laurenzana, Antonella Caivano, Francesco La Rocca, Oreste Villani, Giovanna Mansueto, Giovanna Rosaria Mansueto, Silvia Deaglio, Idanna Innocenti, Luca Laurenti, Stefano Molica, Giuseppe Pietrantuono, Angelo De Stradis, Luigi Del Vecchio, Pellegrino Musto

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30 Citations (Scopus)

Abstract

Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	LEUKEMIA & LYMPHOMA
Volume	14
DOIs	https://doi.org/10.1080/10428194.2016.1243790
Publication status	Published - 2016

Keywords

Cancer Research
Chronic lymphocytic leukemia
Hematology
Oncology
flow cytometry
microvesicles
prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428194.2016.1243790

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De Luca, L., D’Arena, G., Simeon, V., Trino, S., Laurenzana, I., Caivano, A., La Rocca, F., Villani, O., Mansueto, G., Mansueto, G. R., Deaglio, S., Innocenti, I., Laurenti, L., Molica, S., Pietrantuono, G., De Stradis, A., Del Vecchio, L., & Musto, P. (2016). Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia. LEUKEMIA & LYMPHOMA, 14, 1-9. https://doi.org/10.1080/10428194.2016.1243790

@article{52c7b1870be844989f183eda8b61dc27,

title = "Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia",

abstract = "Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL.",

keywords = "Cancer Research, Chronic lymphocytic leukemia, Hematology, Oncology, flow cytometry, microvesicles, prognosis, Cancer Research, Chronic lymphocytic leukemia, Hematology, Oncology, flow cytometry, microvesicles, prognosis",

author = "{De Luca}, Luciana and Giovanni D{\textquoteright}Arena and Vittorio Simeon and Stefania Trino and Ilaria Laurenzana and Antonella Caivano and {La Rocca}, Francesco and Oreste Villani and Giovanna Mansueto and Mansueto, {Giovanna Rosaria} and Silvia Deaglio and Idanna Innocenti and Luca Laurenti and Stefano Molica and Giuseppe Pietrantuono and {De Stradis}, Angelo and {Del Vecchio}, Luigi and Pellegrino Musto",

year = "2016",

doi = "10.1080/10428194.2016.1243790",

language = "English",

volume = "14",

pages = "1--9",

journal = "LEUKEMIA & LYMPHOMA",

issn = "1042-8194",

publisher = "Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: [email protected], [email protected], INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245",

}

De Luca, L, D’Arena, G, Simeon, V, Trino, S, Laurenzana, I, Caivano, A, La Rocca, F, Villani, O, Mansueto, G, Mansueto, GR, Deaglio, S, Innocenti, I, Laurenti, L, Molica, S, Pietrantuono, G, De Stradis, A, Del Vecchio, L & Musto, P 2016, 'Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia', LEUKEMIA & LYMPHOMA, vol. 14, pp. 1-9. https://doi.org/10.1080/10428194.2016.1243790

TY - JOUR

T1 - Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

AU - De Luca, Luciana

AU - D’Arena, Giovanni

AU - Simeon, Vittorio

AU - Trino, Stefania

AU - Laurenzana, Ilaria

AU - Caivano, Antonella

AU - La Rocca, Francesco

AU - Villani, Oreste

AU - Mansueto, Giovanna

AU - Mansueto, Giovanna Rosaria

AU - Deaglio, Silvia

AU - Innocenti, Idanna

AU - Laurenti, Luca

AU - Molica, Stefano

AU - Pietrantuono, Giuseppe

AU - De Stradis, Angelo

AU - Del Vecchio, Luigi

AU - Musto, Pellegrino

PY - 2016

Y1 - 2016

N2 - Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL.

AB - Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL.

KW - Cancer Research

KW - Chronic lymphocytic leukemia

KW - Hematology

KW - Oncology

KW - flow cytometry

KW - microvesicles

KW - prognosis

KW - Cancer Research

KW - Chronic lymphocytic leukemia

KW - Hematology

KW - Oncology

KW - flow cytometry

KW - microvesicles

KW - prognosis

UR - http://hdl.handle.net/10807/94553

U2 - 10.1080/10428194.2016.1243790

DO - 10.1080/10428194.2016.1243790

M3 - Article

SN - 1042-8194

VL - 14

SP - 1

EP - 9

JO - LEUKEMIA & LYMPHOMA

JF - LEUKEMIA & LYMPHOMA

ER -

Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

Abstract

Keywords

UN SDGs

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