Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

G. Bogani; G. Scambia; C. Cimmino; Francesco Fanfani; B. Costantini; M. Loverro; Maria Gabriella Ferrandina; F. Landoni; L. Bazzurini; T. Grassi; D. Vitobello; G. Siesto; A. M. Perrone; V. Zanagnolo; Iaco P. De; F. Multinu; F. Ghezzi; J. Casarin; R. Berretta; V. A. Capozzi; E. Zupi; G. Centini; A. Pellegrino; S. Corso; G. Stevenazzi; S. Montoli; A. C. Boschi; G. Comerci; P. Greco; R. Martinello; F. Sopracordevole; G. Giorda; T. Simoncini; M. Caretto; E. Sartori; F. Ferrari; A. Cianci; G. Sarpietro; M. G. Matarazzo; F. Zullo; G. Bifulco; M. Morelli; A. Ferrero; N. Biglia; F. Barra; S. Ferrero; U. L. R. Maggiore; S. Cianci; V. Chiantera; A. Ercoli; G. Sozzi; A. Martoccia; S. Schettini; T. Orlando; F. G. Cannone; G. Ettore; A. Puppo; M. Borghese; C. Martinelli; L. Muzii; Donato V. Di; L. Driul; S. Restaino; A. Bergamini; G. Candotti; L. Bocciolone; F. Plotti; R. Angioli; G. Mantovani; M. Ceccaroni; C. Cassani; M. Dominoni; L. Giambanco; S. Amodeo; L. Leo; R. Thomasset; D. Raimondo; R. Seracchioli; M. Malzoni; F. Gorlero; Luca M. Di; E. Busato; S. Kilzie; A. Dell'acqua; G. Scarfone; P. Vercellini; M. Petrillo; S. Dessole; G. Capobianco; A. Ciavattini; Carpini G. Delli; L. Giannella; L. Mereu; S. Tateo; F. Sorbi; M. Fambrini; S. Cicogna; F. Romano; G. Ricci; G. Trojano; R. Consonni; S. Cantaluppi; A. Lippolis; R. Tinelli; G. D'ippolito; L. Aguzzoli; V. D. Mandato; S. Palomba; D. Calandra; M. Rosati; C. Gallo; D. Surico; V. Remorgida; F. Ruscitto; P. Beretta; P. B. Panici; F. Raspagliesi

doi:10.3802/JGO.2022.33.E10

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

G. Bogani^*
, G. Scambia
, C. Cimmino^*
, Francesco Fanfani
, B. Costantini
, M. Loverro
, Maria Gabriella Ferrandina
, F. Landoni
, L. Bazzurini
, T. Grassi
, D. Vitobello
, G. Siesto
, A. M. Perrone
, V. Zanagnolo
, Iaco P. De
, F. Multinu
, F. Ghezzi
, J. Casarin
, R. Berretta
, V. A. Capozzi

E. Zupi, G. Centini, A. Pellegrino, S. Corso, G. Stevenazzi, S. Montoli, A. C. Boschi, G. Comerci, P. Greco, R. Martinello, F. Sopracordevole, G. Giorda, T. Simoncini, M. Caretto, E. Sartori, F. Ferrari, A. Cianci, G. Sarpietro, M. G. Matarazzo, F. Zullo, G. Bifulco, M. Morelli, A. Ferrero, N. Biglia, F. Barra, S. Ferrero, U. L. R. Maggiore, S. Cianci, V. Chiantera, A. Ercoli, G. Sozzi, A. Martoccia, S. Schettini, T. Orlando, F. G. Cannone, G. Ettore, A. Puppo, M. Borghese, C. Martinelli, L. Muzii, Donato V. Di, L. Driul, S. Restaino, A. Bergamini, G. Candotti, L. Bocciolone, F. Plotti, R. Angioli, G. Mantovani, M. Ceccaroni, C. Cassani, M. Dominoni, L. Giambanco, S. Amodeo, L. Leo, R. Thomasset, D. Raimondo, R. Seracchioli, M. Malzoni, F. Gorlero, Luca M. Di, E. Busato, S. Kilzie, A. Dell'acqua, G. Scarfone, P. Vercellini, M. Petrillo, S. Dessole, G. Capobianco, A. Ciavattini, Carpini G. Delli, L. Giannella, L. Mereu, S. Tateo, F. Sorbi, M. Fambrini, S. Cicogna, F. Romano, G. Ricci, G. Trojano, R. Consonni, S. Cantaluppi, A. Lippolis, R. Tinelli, G. D'ippolito, L. Aguzzoli, V. D. Mandato, S. Palomba, D. Calandra, M. Rosati, C. Gallo, D. Surico, V. Remorgida, F. Ruscitto, P. Beretta, P. B. Panici, F. Raspagliesi

^*Corresponding author

IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
University of Insubria
Azienda Ospedaliera San Gerardo Monza
IRCCS Istituto Clinico Humanitas - Rozzano (Milano)
IRCCS Istituto Europeo di Oncologia - Milano
Alma Mater Studiorum University of Bologna
University of Parma
University of Siena
Azienda Ospedaliera Ospedale Di Lecco
Legnano (Milan) Hospital
Ospedale S. Maria delle Croci
University of Ferrara
IRCCS Centro di Riferimento Oncologico - Aviano PN
University of Pisa
University of Brescia
University of Catania
Azienda Ospedaliera Universitaria Federico II
AO “S.S. Annunziata”
Ospedale Mauriziano Umberto I
San Martino Hospital Genoa
University of Messina
University of Palermo
AOR San Carlo
ARNAS Garibaldi Catania
S. Croce General Hospital
University of Rome La Sapienza
University Hospital Udine
San Raffaele Scientific Institute
Universita Campus Bio-Medico di Roma
Sacred Heart Hospital
IRCCS Fondazione Policlinico San Matteo - Pavia
Azienda Ospedaliera S. Antonio di Abate di Trapani
AUSL Valleè d'Aoste
Center for Advanced Endoscopic Gynecologic Surgery
E.O. Ospedali Galliera
Ospedale Regionale S. Maria dei Battuti
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
University of Sassari
Marche Polytechnic University
Ospedale S. Chiara
Azienda Ospedaliera Careggi
IRCCS Ospedale Infantile Burlo Garofolo - Trieste
University of Trieste
Madonna delle Grazie Hospital ASM

Research output: Contribution to journal › Article

Abstract

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

Original language	English
Pages (from-to)	50-56
Number of pages	7
Journal	Journal of Gynecologic Oncology
Volume	33
Issue number	1
DOIs	https://doi.org/10.3802/JGO.2022.33.E10
Publication status	Published - 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Obstetrics and Gynaecology

Keywords

COVID-19
Endometrial Cancer
Endometrial Neoplasms
Female
Humans
Pandemics
Retrospective Studies
SARS-CoV-2
Uterine cancer

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10.3802/JGO.2022.33.E10

Cite this

Bogani, G., Scambia, G., Cimmino, C., Fanfani, F., Costantini, B., Loverro, M., Ferrandina, M. G., Landoni, F., Bazzurini, L., Grassi, T., Vitobello, D., Siesto, G., Perrone, A. M., Zanagnolo, V., De, I. P., Multinu, F., Ghezzi, F., Casarin, J., Berretta, R., ... Raspagliesi, F. (2022). Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic. Journal of Gynecologic Oncology, 33(1), 50-56. https://doi.org/10.3802/JGO.2022.33.E10

@article{f0ed9589c63942b994770648b37b9d45,

title = "Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic",

abstract = "Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3\%) and 484 (21.2\%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7\% in period 1 vs. 52.8\% in period 2; p<0.001). Overall, 1,280 (50.4\%) and 1,021 (44.7\%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.",

keywords = "COVID-19, Endometrial Cancer, Endometrial Neoplasms, Female, Humans, Pandemics, Retrospective Studies, SARS-CoV-2, Uterine cancer, COVID-19, Endometrial Cancer, Endometrial Neoplasms, Female, Humans, Pandemics, Retrospective Studies, SARS-CoV-2, Uterine cancer",

author = "G. Bogani and G. Scambia and C. Cimmino and Francesco Fanfani and B. Costantini and M. Loverro and Ferrandina, \{Maria Gabriella\} and F. Landoni and L. Bazzurini and T. Grassi and D. Vitobello and G. Siesto and Perrone, \{A. M.\} and V. Zanagnolo and De, \{Iaco P.\} and F. Multinu and F. Ghezzi and J. Casarin and R. Berretta and Capozzi, \{V. A.\} and E. Zupi and G. Centini and A. Pellegrino and S. Corso and G. Stevenazzi and S. Montoli and Boschi, \{A. C.\} and G. Comerci and P. Greco and R. Martinello and F. Sopracordevole and G. Giorda and T. Simoncini and M. Caretto and E. Sartori and F. Ferrari and A. Cianci and G. Sarpietro and Matarazzo, \{M. G.\} and F. Zullo and G. Bifulco and M. Morelli and A. Ferrero and N. Biglia and F. Barra and S. Ferrero and Maggiore, \{U. L. R.\} and S. Cianci and V. Chiantera and A. Ercoli and G. Sozzi and A. Martoccia and S. Schettini and T. Orlando and Cannone, \{F. G.\} and G. Ettore and A. Puppo and M. Borghese and C. Martinelli and L. Muzii and Di, \{Donato V.\} and L. Driul and S. Restaino and A. Bergamini and G. Candotti and L. Bocciolone and F. Plotti and R. Angioli and G. Mantovani and M. Ceccaroni and C. Cassani and M. Dominoni and L. Giambanco and S. Amodeo and L. Leo and R. Thomasset and D. Raimondo and R. Seracchioli and M. Malzoni and F. Gorlero and Di, \{Luca M.\} and E. Busato and S. Kilzie and A. Dell'acqua and G. Scarfone and P. Vercellini and M. Petrillo and S. Dessole and G. Capobianco and A. Ciavattini and Delli, \{Carpini G.\} and L. Giannella and L. Mereu and S. Tateo and F. Sorbi and M. Fambrini and S. Cicogna and F. Romano and G. Ricci and G. Trojano and R. Consonni and S. Cantaluppi and A. Lippolis and R. Tinelli and G. D'ippolito and L. Aguzzoli and Mandato, \{V. D.\} and S. Palomba and D. Calandra and M. Rosati and C. Gallo and D. Surico and V. Remorgida and F. Ruscitto and P. Beretta and Panici, \{P. B.\} and F. Raspagliesi",

year = "2022",

doi = "10.3802/JGO.2022.33.E10",

language = "English",

volume = "33",

pages = "50--56",

journal = "Journal of Gynecologic Oncology",

issn = "2005-0380",

publisher = "Korean Society of Gynecologic Oncology and Colposcopy",

number = "1",

}

Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, MG, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, AM, Zanagnolo, V, De, IP, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, VA, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, AC, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, MG, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Maggiore, ULR, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, FG, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di, DV, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di, LM, Busato, E, Kilzie, S, Dell'acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli, CG, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'ippolito, G, Aguzzoli, L, Mandato, VD, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Panici, PB & Raspagliesi, F 2022, 'Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic', Journal of Gynecologic Oncology, vol. 33, no. 1, pp. 50-56. https://doi.org/10.3802/JGO.2022.33.E10

TY - JOUR

T1 - Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

AU - Bogani, G.

AU - Scambia, G.

AU - Cimmino, C.

AU - Fanfani, Francesco

AU - Costantini, B.

AU - Loverro, M.

AU - Ferrandina, Maria Gabriella

AU - Landoni, F.

AU - Bazzurini, L.

AU - Grassi, T.

AU - Vitobello, D.

AU - Siesto, G.

AU - Perrone, A. M.

AU - Zanagnolo, V.

AU - De, Iaco P.

AU - Multinu, F.

AU - Ghezzi, F.

AU - Casarin, J.

AU - Berretta, R.

AU - Capozzi, V. A.

AU - Zupi, E.

AU - Centini, G.

AU - Pellegrino, A.

AU - Corso, S.

AU - Stevenazzi, G.

AU - Montoli, S.

AU - Boschi, A. C.

AU - Comerci, G.

AU - Greco, P.

AU - Martinello, R.

AU - Sopracordevole, F.

AU - Giorda, G.

AU - Simoncini, T.

AU - Caretto, M.

AU - Sartori, E.

AU - Ferrari, F.

AU - Cianci, A.

AU - Sarpietro, G.

AU - Matarazzo, M. G.

AU - Zullo, F.

AU - Bifulco, G.

AU - Morelli, M.

AU - Ferrero, A.

AU - Biglia, N.

AU - Barra, F.

AU - Ferrero, S.

AU - Maggiore, U. L. R.

AU - Cianci, S.

AU - Chiantera, V.

AU - Ercoli, A.

AU - Sozzi, G.

AU - Martoccia, A.

AU - Schettini, S.

AU - Orlando, T.

AU - Cannone, F. G.

AU - Ettore, G.

AU - Puppo, A.

AU - Borghese, M.

AU - Martinelli, C.

AU - Muzii, L.

AU - Di, Donato V.

AU - Driul, L.

AU - Restaino, S.

AU - Bergamini, A.

AU - Candotti, G.

AU - Bocciolone, L.

AU - Plotti, F.

AU - Angioli, R.

AU - Mantovani, G.

AU - Ceccaroni, M.

AU - Cassani, C.

AU - Dominoni, M.

AU - Giambanco, L.

AU - Amodeo, S.

AU - Leo, L.

AU - Thomasset, R.

AU - Raimondo, D.

AU - Seracchioli, R.

AU - Malzoni, M.

AU - Gorlero, F.

AU - Di, Luca M.

AU - Busato, E.

AU - Kilzie, S.

AU - Dell'acqua, A.

AU - Scarfone, G.

AU - Vercellini, P.

AU - Petrillo, M.

AU - Dessole, S.

AU - Capobianco, G.

AU - Ciavattini, A.

AU - Delli, Carpini G.

AU - Giannella, L.

AU - Mereu, L.

AU - Tateo, S.

AU - Sorbi, F.

AU - Fambrini, M.

AU - Cicogna, S.

AU - Romano, F.

AU - Ricci, G.

AU - Trojano, G.

AU - Consonni, R.

AU - Cantaluppi, S.

AU - Lippolis, A.

AU - Tinelli, R.

AU - D'ippolito, G.

AU - Aguzzoli, L.

AU - Mandato, V. D.

AU - Palomba, S.

AU - Calandra, D.

AU - Rosati, M.

AU - Gallo, C.

AU - Surico, D.

AU - Remorgida, V.

AU - Ruscitto, F.

AU - Beretta, P.

AU - Panici, P. B.

AU - Raspagliesi, F.

PY - 2022

Y1 - 2022

N2 - Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

AB - Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

KW - COVID-19

KW - Endometrial Cancer

KW - Endometrial Neoplasms

KW - Female

KW - Humans

KW - Pandemics

KW - Retrospective Studies

KW - SARS-CoV-2

KW - Uterine cancer

KW - COVID-19

KW - Endometrial Cancer

KW - Endometrial Neoplasms

KW - Female

KW - Humans

KW - Pandemics

KW - Retrospective Studies

KW - SARS-CoV-2

KW - Uterine cancer

UR - https://publicatt.unicatt.it/handle/10807/198485

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85123227180&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123227180&origin=inward

U2 - 10.3802/JGO.2022.33.E10

DO - 10.3802/JGO.2022.33.E10

M3 - Article

SN - 2005-0380

VL - 33

SP - 50

EP - 56

JO - Journal of Gynecologic Oncology

JF - Journal of Gynecologic Oncology

IS - 1

ER -

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Abstract

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