Challenges in crohn’s disease management after gastrointestinal cancer diagnosis

Fausto Rosa, Luigi Natale, Giampaolo Tortora, Alessandro Armuzzi, Sergio Alfieri, Claudio Fiorillo, Carlo Alberto Schena, Giuseppe Quero, Vito Laterza, Tommaso Schepis, Lisa Salvatore, Luigi Larosa, Laura Maria Minordi

Research output: Contribution to journalArticle

Abstract

Crohnʹs disease (CD) is a chronic inflammatory bowel disease with a progressive course, potentially affecting the entire gastrointestinal tract from mouth to anus. Several studies have shown an increased risk of both intestinal and extra‐intestinal cancer in patients with CD, due to long‐standing transmural inflammation and damage accumulation. The similarity of symptoms among CD, its related complications and the de novo onset of gastrointestinal cancer raises difficulties in the differential diagnosis. In addition, once a cancer diagnosis in CD patients is made, selecting the appropriate treatment can be particularly challenging. Indeed, both surgical and oncological treatments are not always the same as that of the general population, due to the inflammatory context of the gastrointestinal tract and the potential exacerbation of gastrointestinal symptoms of patients with CD; moreover, the overlap of the neoplastic disease could lead to adjustments in the pharmacological treatment of the underlying CD, especially with regard to immunosuppressive drugs. For these reasons, a case‐by‐case analysis in a multidisciplinary approach is often appropriate for the best diagnostic and therapeutic evaluation of patients with CD after gastrointestinal cancer onset.
Original languageEnglish
Pages (from-to)1-26
Number of pages26
JournalCancers
Volume13
DOIs
Publication statusPublished - 2021

Keywords

  • Anal cancer
  • Colorectal cancer
  • Small bowel cancer
  • Multidisciplinary approach
  • Crohn’s disease

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