Central conduction abnormalities in patients receiving levodopa-carbidopa intestinal gel infusion

Francesco Bove, Marco Luigetti, Lara Gallicchio, Valentina Recchia, Antonella Petruzzellis, Riccardo Di Iorio, Filippo Tamma, Alfonso Fasano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


In recent years, several studies have reported a relatively high frequency of polyneuropathy in patients with Parkinson’s disease (PD), in particular, in patients receiving levodopa-carbidopa intestinal gel (LCIG) infusion. In spite of the several patients investigated with nerve conduction studies, no study has prospectively explored a possible central nervous system involvement of patients receiving LCIG infusion. We prospectively evaluated eight PD patients receiving LCIG infusion, who underwent neurophysiological evaluations with nerve conduction studies, visual, somatosensory and motor evoked potentials before LCIG infusion, and 1 and 6 months after. At 6 months follow-up, we found significant reduction in sural nerve SNAP amplitude, increase of central sensory conduction time N22-P40, and increases of central motor conduction time recorded from I dorsal interosseous and tibialis anterior. In PD patients with LCIG infusion, we found a subclinical neurophysiological impairment of both peripheral and central nervous system.
Original languageEnglish
Pages (from-to)1869-1872
Number of pages4
JournalNeurological Sciences
Publication statusPublished - 2017


  • 2708
  • Aged
  • Antiparkinson Agents
  • Carbidopa
  • Central Nervous System
  • Clinical neurophysiology
  • Drug Combinations
  • Electromyography (EMG)
  • Evoked potentials
  • Female
  • Follow-Up Studies
  • Gels
  • Humans
  • Infusions, Parenteral
  • Levodopa
  • Male
  • Neural Conduction
  • Neurology (clinical)
  • Neuropharmacology
  • Parkinson Disease
  • Parkinson’s disease
  • Peripheral Nervous System
  • Polyneuropathies
  • Prospective Studies
  • Psychiatry and Mental Health


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