Cellular stress marker alteration and inflammatory response in pigs
fed with an ochratoxin contaminated diet

Chiara Bernardini; Terenzio Bertuzzi; Ester Grilli; Johanna Catharina Duvigneau; Augusta Zannoni; Benedetta Tugnoli; Fabio Gentilini; Silvia Spinozzi; Cecilia Camborata; Maria Laura Bacci; Andrea Piva; Monica Forni

doi:10.1016/j.rvsc.2014.07.018

Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet

Chiara Bernardini, Terenzio Bertuzzi, Ester Grilli, Johanna Catharina Duvigneau, Augusta Zannoni, Benedetta Tugnoli, Fabio Gentilini, Silvia Spinozzi, Cecilia Camborata, Maria Laura Bacci, Andrea Piva, Monica Forni

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity of immune system of weaned pigs. Growth performance was not affected by OTA consumption even if OTA levels increased in plasma, kidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha and IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased in the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to respond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our findings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for the animal and virtually for human health, pig being an excellent model for human.

Original language	English
Pages (from-to)	244-250
Journal	Research in Veterinary Science
Volume	97
DOIs	https://doi.org/10.1016/j.rvsc.2014.07.018
Publication status	Published - 2014

Keywords

OTA, PIG

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.rvsc.2014.07.018

Cite this

Bernardini, C., Bertuzzi, T., Grilli, E., Duvigneau, J. C., Zannoni, A., Tugnoli, B., Gentilini, F., Spinozzi, S., Camborata, C., Bacci, M. L., Piva, A., & Forni, M. (2014). Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet. Research in Veterinary Science, 97, 244-250. https://doi.org/10.1016/j.rvsc.2014.07.018

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title = "Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet",

abstract = "on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity of immune system of weaned pigs. Growth performance was not affected by OTA consumption even if OTA levels increased in plasma, kidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha and IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased in the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to respond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our findings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for the animal and virtually for human health, pig being an excellent model for human.",

keywords = "OTA, PIG, OTA, PIG",

author = "Chiara Bernardini and Terenzio Bertuzzi and Ester Grilli and Duvigneau, {Johanna Catharina} and Augusta Zannoni and Benedetta Tugnoli and Fabio Gentilini and Silvia Spinozzi and Cecilia Camborata and Bacci, {Maria Laura} and Andrea Piva and Monica Forni",

year = "2014",

doi = "10.1016/j.rvsc.2014.07.018",

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T1 - Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet

AU - Bernardini, Chiara

AU - Bertuzzi, Terenzio

AU - Grilli, Ester

AU - Duvigneau, Johanna Catharina

AU - Zannoni, Augusta

AU - Tugnoli, Benedetta

AU - Gentilini, Fabio

AU - Spinozzi, Silvia

AU - Camborata, Cecilia

AU - Bacci, Maria Laura

AU - Piva, Andrea

AU - Forni, Monica

PY - 2014

Y1 - 2014

N2 - on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity of immune system of weaned pigs. Growth performance was not affected by OTA consumption even if OTA levels increased in plasma, kidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha and IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased in the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to respond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our findings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for the animal and virtually for human health, pig being an excellent model for human.

AB - on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity of immune system of weaned pigs. Growth performance was not affected by OTA consumption even if OTA levels increased in plasma, kidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha and IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased in the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to respond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our findings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for the animal and virtually for human health, pig being an excellent model for human.

KW - OTA, PIG

UR - http://hdl.handle.net/10807/61454

U2 - 10.1016/j.rvsc.2014.07.018

DO - 10.1016/j.rvsc.2014.07.018

M3 - Article

SN - 0034-5288

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SP - 244

EP - 250

JO - Research in Veterinary Science

JF - Research in Veterinary Science

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