Cellular and molecular aspects of drugs of the future: oxaliplatin

Riccardo Riccardi, Angela Maria Di Francesco, Antonio Ruggiero

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Oxaliplatin (Eloxatine) is a third-generation platinum compound which has shown a wide antitumour effect both in vitro and in vivo, a better safety profile than cisplatin and a lack of cross-resistance with cisplatin and carboplatin. In this scenario, oxaliplatin may represent an innovative and challenging drug extending the antitumour activity in diseases such as gastrointestinal cancer that are not usually sensitive to these coordination complexes. Oxaliplatin has a non-hydrolysable diaminocyclohexane (DACH) carrier ligand which is maintained in the final cytotoxic metabolites of the drug. Like cisplatin, oxaliplatin targets DNA producing mainly 1,2-GG intrastrand cross-links. The cellular and molecular aspects of the mechanism of action of oxaliplatin have not yet been fully elucidated. However, the intrinsic chemical and steric characteristics of the DACH-platinum adducts appear to contribute to the lack of cross-resistance with cisplatin. To date, mismatch repair and replicative bypass appear to be the processes most likely involved in differentiating the molecular responses to these agents.
Original languageEnglish
Pages (from-to)1914-1927
Number of pages14
JournalCellular and Molecular Life Sciences
Volume59
DOIs
Publication statusPublished - 2002

Keywords

  • anticancer drug
  • oxaliplatin

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