CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Giampaolo Niccoli; Rosanna Apa; Antonio Lanzone; Giovanna Liuzzo; Cristina Spaziani; Francesca Sagnella; Nicola Cosentino; Francesca Moro; Daniela Martinez; Andrea Morciano; Marco Baca'; Vincenzo Pazzano; Maria Francesca Gangale; Anna Tropea; Filippo Crea

doi:10.1016/j.fertnstert.2011.01.129

CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Giampaolo Niccoli, Rosanna Apa, Antonio Lanzone, Giovanna Liuzzo, Cristina Spaziani, Francesca Sagnella, Nicola Cosentino, Francesca Moro, Daniela Martinez, Andrea Morciano, Marco Baca', Vincenzo Pazzano, Maria Francesca Gangale, Anna Tropea, Filippo Crea

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

Original language	English
Pages (from-to)	2651-2654
Number of pages	4
Journal	Fertility and Sterility
Volume	2011
DOIs	https://doi.org/10.1016/j.fertnstert.2011.01.129
Publication status	Published - 2011

Keywords

Inflammation
hyperinsulinemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fertnstert.2011.01.129

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Niccoli, G., Apa, R., Lanzone, A., Liuzzo, G., Spaziani, C., Sagnella, F., Cosentino, N., Moro, F., Martinez, D., Morciano, A., Baca', M., Pazzano, V., Gangale, M. F., Tropea, A., & Crea, F. (2011). CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome. Fertility and Sterility, 2011, 2651-2654. https://doi.org/10.1016/j.fertnstert.2011.01.129

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title = "CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome",

abstract = "Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.",

keywords = "Inflammation, hyperinsulinemia, Inflammation, hyperinsulinemia",

author = "Giampaolo Niccoli and Rosanna Apa and Antonio Lanzone and Giovanna Liuzzo and Cristina Spaziani and Francesca Sagnella and Nicola Cosentino and Francesca Moro and Daniela Martinez and Andrea Morciano and Marco Baca' and Vincenzo Pazzano and Gangale, {Maria Francesca} and Anna Tropea and Filippo Crea",

year = "2011",

doi = "10.1016/j.fertnstert.2011.01.129",

language = "English",

volume = "2011",

pages = "2651--2654",

journal = "Fertility and Sterility",

issn = "0015-0282",

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TY - JOUR

T1 - CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

AU - Niccoli, Giampaolo

AU - Apa, Rosanna

AU - Lanzone, Antonio

AU - Liuzzo, Giovanna

AU - Spaziani, Cristina

AU - Sagnella, Francesca

AU - Cosentino, Nicola

AU - Moro, Francesca

AU - Martinez, Daniela

AU - Morciano, Andrea

AU - Baca', Marco

AU - Pazzano, Vincenzo

AU - Gangale, Maria Francesca

AU - Tropea, Anna

AU - Crea, Filippo

PY - 2011

Y1 - 2011

N2 - Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

AB - Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

KW - Inflammation

KW - hyperinsulinemia

KW - Inflammation

KW - hyperinsulinemia

UR - http://hdl.handle.net/10807/2097

U2 - 10.1016/j.fertnstert.2011.01.129

DO - 10.1016/j.fertnstert.2011.01.129

M3 - Article

SN - 0015-0282

VL - 2011

SP - 2651

EP - 2654

JO - Fertility and Sterility

JF - Fertility and Sterility

ER -

CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Abstract

Keywords

UN SDGs

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