Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Salvatore Zaffina; Eva Piano Mortari; Reparata Rosa Di Prinzio; Marco Cappa; Antonio Novelli; Emanuele Agolini; Massimiliano Raponi; Bruno Dallapiccola; Franco Locatelli; Carlo Federico Perno; Rita Carsetti

doi:10.3389/fimmu.2022.869042

Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Salvatore Zaffina, Eva Piano Mortari, Reparata Rosa Di Prinzio, Marco Cappa, Antonio Novelli, Emanuele Agolini, Massimiliano Raponi, Bruno Dallapiccola, Franco Locatelli, Carlo Federico Perno, Rita Carsetti

IRCCS Ospedale pediatrico Bambino Gesù - Roma

Research output: Contribution to journal › Article

Abstract

A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Frontiers in Immunology
Volume	13
DOIs	https://doi.org/10.3389/fimmu.2022.869042
Publication status	Published - 2022

Keywords

case report
CAVIN1
SARS-CoV-2 vaccine
memory B cells
congenital generalized lipodystrophy type 4

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fimmu.2022.869042

Cite this

Zaffina, S., Piano Mortari, E., Di Prinzio, R. R., Cappa, M., Novelli, A., Agolini, E., Raponi, M., Dallapiccola, B., Locatelli, F., Perno, C. F., & Carsetti, R. (2022). Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4. Frontiers in Immunology, 13, 1-6. https://doi.org/10.3389/fimmu.2022.869042

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title = "Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4",

abstract = "A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.",

keywords = "case report, CAVIN1, SARS-CoV-2 vaccine, memory B cells, congenital generalized lipodystrophy type 4, case report, CAVIN1, SARS-CoV-2 vaccine, memory B cells, congenital generalized lipodystrophy type 4",

author = "Salvatore Zaffina and {Piano Mortari}, Eva and {Di Prinzio}, {Reparata Rosa} and Marco Cappa and Antonio Novelli and Emanuele Agolini and Massimiliano Raponi and Bruno Dallapiccola and Franco Locatelli and Perno, {Carlo Federico} and Rita Carsetti",

year = "2022",

doi = "10.3389/fimmu.2022.869042",

language = "English",

volume = "13",

pages = "1--6",

journal = "Frontiers in Immunology",

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Zaffina, S, Piano Mortari, E, Di Prinzio, RR, Cappa, M, Novelli, A, Agolini, E, Raponi, M, Dallapiccola, B, Locatelli, F, Perno, CF & Carsetti, R 2022, 'Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4', Frontiers in Immunology, vol. 13, pp. 1-6. https://doi.org/10.3389/fimmu.2022.869042

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AU - Zaffina, Salvatore

AU - Piano Mortari, Eva

AU - Di Prinzio, Reparata Rosa

AU - Cappa, Marco

AU - Novelli, Antonio

AU - Agolini, Emanuele

AU - Raponi, Massimiliano

AU - Dallapiccola, Bruno

AU - Locatelli, Franco

AU - Perno, Carlo Federico

AU - Carsetti, Rita

PY - 2022

Y1 - 2022

N2 - A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.

AB - A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.

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KW - SARS-CoV-2 vaccine

KW - memory B cells

KW - congenital generalized lipodystrophy type 4

KW - case report

KW - CAVIN1

KW - SARS-CoV-2 vaccine

KW - memory B cells

KW - congenital generalized lipodystrophy type 4

UR - http://hdl.handle.net/10807/229770

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DO - 10.3389/fimmu.2022.869042

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SN - 1664-3224

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JF - Frontiers in Immunology

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Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Abstract

Keywords

UN SDGs

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