Cancer stem cell definitions and terminology: The devil is in the details

Peter Valent; Dominique Bonnet; Ruggero De Maria Marchiano; Tsvee Lapidot; Mhairi Copland; Junia V. Melo; Christine Chomienne; Fumihiko Ishikawa; Jan Jacob Schuringa; Giorgio Stassi; Brian Huntly; Harald Herrmann; Jean Soulier; Alexander Roesch; Gerrit Jan Schuurhuis; Stefan Wöhrer; Michel Arock; Johannes Zuber; Sabine Cerny-Reiterer; Hans E. Johnsen; Michael Andreeff; Connie Eaves

doi:10.1038/nrc3368

Cancer stem cell definitions and terminology: The devil is in the details

Peter Valent^*
, Dominique Bonnet
, Ruggero De Maria Marchiano
, Tsvee Lapidot
, Mhairi Copland
, Junia V. Melo
, Christine Chomienne
, Fumihiko Ishikawa
, Jan Jacob Schuringa
, Giorgio Stassi
, Brian Huntly
, Harald Herrmann
, Jean Soulier
, Alexander Roesch
, Gerrit Jan Schuurhuis
, Stefan Wöhrer
, Michel Arock
, Johannes Zuber
, Sabine Cerny-Reiterer
, Hans E. Johnsen

Michael Andreeff, Connie Eaves

^*Corresponding author

Medical University of Vienna
Cancer Research UK
Weizmann Institute of Science
University of Glasgow
Institute of Medical and Veterinary Science Australia
Imperial College London
Université Paris Cité
RIKEN
University of Groningen
University of Palermo
University of Cambridge
Institut national de la santé et de la recherche médicale
Saarland University
Location VUmc
École normale supérieure Paris-Saclay
Research Institute of Molecular Pathology (IMP)
Aalborg University
University of Texas MD Anderson Cancer Center
British Columbia Cancer Agency

Research output: Contribution to journal › Article

441 Citations (SciVal)

Abstract

The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients. Â© 2012 Macmillan Publishers Limited. All rights reserved.

Original language	English
Pages (from-to)	767-775
Number of pages	9
Journal	Nature Reviews Cancer
Volume	12
Issue number	11
DOIs	https://doi.org/10.1038/nrc3368
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Keywords

Animals
Cancer Research
Cell Differentiation
Cell Transformation
Clonal Evolution
Humans
Neoplastic
Neoplastic Stem Cells
Oncology
Terminology as Topic

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10.1038/nrc3368

Cite this

Valent, P., Bonnet, D., De Maria Marchiano, R., Lapidot, T., Copland, M., Melo, J. V., Chomienne, C., Ishikawa, F., Schuringa, J. J., Stassi, G., Huntly, B., Herrmann, H., Soulier, J., Roesch, A., Schuurhuis, G. J., Wöhrer, S., Arock, M., Zuber, J., Cerny-Reiterer, S., ... Eaves, C. (2012). Cancer stem cell definitions and terminology: The devil is in the details. Nature Reviews Cancer, 12(11), 767-775. https://doi.org/10.1038/nrc3368

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title = "Cancer stem cell definitions and terminology: The devil is in the details",

abstract = "The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients. {\^A}{\textcopyright} 2012 Macmillan Publishers Limited. All rights reserved.",

keywords = "Animals, Cancer Research, Cell Differentiation, Cell Transformation, Clonal Evolution, Humans, Neoplastic, Neoplastic Stem Cells, Oncology, Terminology as Topic, Animals, Cancer Research, Cell Differentiation, Cell Transformation, Clonal Evolution, Humans, Neoplastic, Neoplastic Stem Cells, Oncology, Terminology as Topic",

author = "Peter Valent and Dominique Bonnet and \{De Maria Marchiano\}, Ruggero and Tsvee Lapidot and Mhairi Copland and Melo, \{Junia V.\} and Christine Chomienne and Fumihiko Ishikawa and Schuringa, \{Jan Jacob\} and Giorgio Stassi and Brian Huntly and Harald Herrmann and Jean Soulier and Alexander Roesch and Schuurhuis, \{Gerrit Jan\} and Stefan W{\"o}hrer and Michel Arock and Johannes Zuber and Sabine Cerny-Reiterer and Johnsen, \{Hans E.\} and Michael Andreeff and Connie Eaves",

year = "2012",

doi = "10.1038/nrc3368",

language = "English",

volume = "12",

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journal = "Nature Reviews Cancer",

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Valent, P, Bonnet, D, De Maria Marchiano, R, Lapidot, T, Copland, M, Melo, JV, Chomienne, C, Ishikawa, F, Schuringa, JJ, Stassi, G, Huntly, B, Herrmann, H, Soulier, J, Roesch, A, Schuurhuis, GJ, Wöhrer, S, Arock, M, Zuber, J, Cerny-Reiterer, S, Johnsen, HE, Andreeff, M & Eaves, C 2012, 'Cancer stem cell definitions and terminology: The devil is in the details', Nature Reviews Cancer, vol. 12, no. 11, pp. 767-775. https://doi.org/10.1038/nrc3368

TY - JOUR

T1 - Cancer stem cell definitions and terminology: The devil is in the details

AU - Valent, Peter

AU - Bonnet, Dominique

AU - De Maria Marchiano, Ruggero

AU - Lapidot, Tsvee

AU - Copland, Mhairi

AU - Melo, Junia V.

AU - Chomienne, Christine

AU - Ishikawa, Fumihiko

AU - Schuringa, Jan Jacob

AU - Stassi, Giorgio

AU - Huntly, Brian

AU - Herrmann, Harald

AU - Soulier, Jean

AU - Roesch, Alexander

AU - Schuurhuis, Gerrit Jan

AU - Wöhrer, Stefan

AU - Arock, Michel

AU - Zuber, Johannes

AU - Cerny-Reiterer, Sabine

AU - Johnsen, Hans E.

AU - Andreeff, Michael

AU - Eaves, Connie

PY - 2012

Y1 - 2012

N2 - The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients. Â© 2012 Macmillan Publishers Limited. All rights reserved.

AB - The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients. Â© 2012 Macmillan Publishers Limited. All rights reserved.

KW - Animals

KW - Cancer Research

KW - Cell Differentiation

KW - Cell Transformation

KW - Clonal Evolution

KW - Humans

KW - Neoplastic

KW - Neoplastic Stem Cells

KW - Oncology

KW - Terminology as Topic

KW - Animals

KW - Cancer Research

KW - Cell Differentiation

KW - Cell Transformation

KW - Clonal Evolution

KW - Humans

KW - Neoplastic

KW - Neoplastic Stem Cells

KW - Oncology

KW - Terminology as Topic

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U2 - 10.1038/nrc3368

DO - 10.1038/nrc3368

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VL - 12

SP - 767

EP - 775

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 11

ER -

Cancer stem cell definitions and terminology: The devil is in the details

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

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