Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives

Teresa Mezza, Andrea Giaccari, Giovanna Muscogiuri, Gianpio Sorice, Annamaria Prioletta, R. Ajjan, S. Pilz, R. Scragg, S. L. Volpe, M. D. Witham

Research output: Contribution to journalArticlepeer-review

98 Citations (SciVal)

Abstract

Several studies have shown that vitamin D may play a role in many biochemical mechanisms in addition to bone and calcium metabolism. Recently, vitamin D has sparked widespread interest because of its involvement in the homeostasis of the cardiovascular system. Hypovitaminosis D has been associated with obesity, related to trapping in adipose tissue due to its lipophilic structure. In addition, vitamin D deficiency is associated with increased risk of cardiovascular disease (CVD) and this may be due to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which it might modulate cardiovascular risk are not fully understood. Given this background, in this work we summarise clinical retrospective and prospective observational studies linking vitamin D levels with cardio-metabolic risk factors and vascular outcome. Moreover, we review various randomised controlled trials (RCTs) investigating the effects of vitamin D supplementation on surrogate markers of cardiovascular risk. Considering the high prevalence of hypovitaminosis D among patients with high cardiovascular risk, vitamin D replacement therapy in this population may be warranted; however, further RCTs are urgently needed to establish when to begin vitamin D therapy, as well as to determine the dose and route and duration of administration.
Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume22
DOIs
Publication statusPublished - 2012

Keywords

  • Cardiovascular Diseases
  • Diabetes Mellitus
  • Dietary Supplements
  • Endothelium
  • Humans
  • Obesity
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Vitamin D
  • Vitamin D Deficiency

Fingerprint

Dive into the research topics of 'Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives'. Together they form a unique fingerprint.

Cite this