Calprotectin: two sides of the same coin

Valeria Carnazzo; Serena Redi; Valerio Basile; Patrizia Natali; Francesca Gulli; Francesco Equitani; Mariapaola Marino; Umberto Basile

doi:10.1093/rheumatology/kead405

Calprotectin: two sides of the same coin

Valeria Carnazzo
, Serena Redi
, Valerio Basile
, Patrizia Natali
, Francesca Gulli
, Francesco Equitani
, Mariapaola Marino
, Umberto Basile^*

^*Corresponding author

Research output: Contribution to journal › Article

Abstract

Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating CLP. In fact, this molecule can be measured in different biological fluids: blood, saliva and urine, using different analytic methods that are described in this review. Furthermore, different data confirm the relevant role of serum CLP in autoimmune diseases. In this review we will highlight the correlation between high levels of circulating CLP and specific autoantibodies of major autoimmune pathologies paving the way to the employment of CLP measurement as useful biomarker for monitoring outcome in different pathologies.

Original language	English
Pages (from-to)	26-33
Number of pages	8
Journal	Rheumatology
Volume	63
DOIs	https://doi.org/10.1093/rheumatology/kead405
Publication status	Published - 2024

Keywords

autoimmune diseases
fecal calprotectin
inflammatory bowel disease
serum calprotectin

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10.1093/rheumatology/kead405

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title = "Calprotectin: two sides of the same coin",

abstract = "Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating CLP. In fact, this molecule can be measured in different biological fluids: blood, saliva and urine, using different analytic methods that are described in this review. Furthermore, different data confirm the relevant role of serum CLP in autoimmune diseases. In this review we will highlight the correlation between high levels of circulating CLP and specific autoantibodies of major autoimmune pathologies paving the way to the employment of CLP measurement as useful biomarker for monitoring outcome in different pathologies.",

keywords = "autoimmune diseases, fecal calprotectin, inflammatory bowel disease, serum calprotectin, autoimmune diseases, fecal calprotectin, inflammatory bowel disease, serum calprotectin",

author = "Valeria Carnazzo and Serena Redi and Valerio Basile and Patrizia Natali and Francesca Gulli and Francesco Equitani and Mariapaola Marino and Umberto Basile",

year = "2024",

doi = "10.1093/rheumatology/kead405",

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TY - JOUR

T1 - Calprotectin: two sides of the same coin

AU - Carnazzo, Valeria

AU - Redi, Serena

AU - Basile, Valerio

AU - Natali, Patrizia

AU - Gulli, Francesca

AU - Equitani, Francesco

AU - Marino, Mariapaola

AU - Basile, Umberto

PY - 2024

Y1 - 2024

N2 - Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating CLP. In fact, this molecule can be measured in different biological fluids: blood, saliva and urine, using different analytic methods that are described in this review. Furthermore, different data confirm the relevant role of serum CLP in autoimmune diseases. In this review we will highlight the correlation between high levels of circulating CLP and specific autoantibodies of major autoimmune pathologies paving the way to the employment of CLP measurement as useful biomarker for monitoring outcome in different pathologies.

AB - Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating CLP. In fact, this molecule can be measured in different biological fluids: blood, saliva and urine, using different analytic methods that are described in this review. Furthermore, different data confirm the relevant role of serum CLP in autoimmune diseases. In this review we will highlight the correlation between high levels of circulating CLP and specific autoantibodies of major autoimmune pathologies paving the way to the employment of CLP measurement as useful biomarker for monitoring outcome in different pathologies.

KW - autoimmune diseases

KW - fecal calprotectin

KW - inflammatory bowel disease

KW - serum calprotectin

KW - autoimmune diseases

KW - fecal calprotectin

KW - inflammatory bowel disease

KW - serum calprotectin

UR - http://hdl.handle.net/10807/255955

U2 - 10.1093/rheumatology/kead405

DO - 10.1093/rheumatology/kead405

M3 - Article

SN - 1462-0324

VL - 63

SP - 26

EP - 33

JO - Rheumatology

JF - Rheumatology

ER -

Calprotectin: two sides of the same coin

Abstract

Keywords

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