Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification

Vincenzo Arena, Cristiana Ercolani, Caterina Marchiò, Anna Di Benedetto, Alessandra Fabi, Letizia Perracchio, Patrizia Vici, Francesca Sperati, Simonetta Buglioni, Edoardo Pescarmona, Anna Sapino, Irene Terrenato, Marcella Mottolese

Research output: Contribution to journalArticle

Abstract

This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.
Original languageEnglish
Pages (from-to)143-153
Number of pages11
JournalJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOIs
Publication statusPublished - 2017

Keywords

  • HER2, Amplification

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