Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification

Vincenzo Arena

doi:10.1186/s13046-017-0613-2

Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification

Research output: Contribution to journal › Article

Abstract

This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.

Original language	English
Pages (from-to)	143-153
Number of pages	11
Journal	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume	36
DOIs	https://doi.org/10.1186/s13046-017-0613-2
Publication status	Published - 2017

Keywords

HER2, Amplification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13046-017-0613-2

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title = "Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification",

abstract = "This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.",

keywords = "HER2, Amplification, HER2, Amplification",

author = "Vincenzo Arena",

year = "2017",

doi = "10.1186/s13046-017-0613-2",

language = "English",

volume = "36",

pages = "143--153",

journal = "JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH",

issn = "0392-9078",

publisher = "Attuale:APSIT ASSOC PROM STUD IMMUNOL TUMOR, VIALE REGINA ELENA 291, ROME, ITALY, 00161 Centro Ricerca Sperimentale:Via Delle Messi d Oro 156, 00158 Rome Italy:011 39 06 52662536, EMAIL: [email protected], INTERNET: http://crs.ifo.it, Fax: 011 39 06 52662505",

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TY - JOUR

T1 - Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification

AU - Arena, Vincenzo

PY - 2017

Y1 - 2017

N2 - This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.

AB - This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.

KW - HER2, Amplification

UR - http://hdl.handle.net/10807/153758

U2 - 10.1186/s13046-017-0613-2

DO - 10.1186/s13046-017-0613-2

M3 - Article

SN - 0392-9078

VL - 36

SP - 143

EP - 153

JO - JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

JF - JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ER -

Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification

Abstract

Keywords

UN SDGs

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