Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis

Claudio Sandroni; Tobias Cronberg; Mypinder Sekhon

doi:10.1007/s00134-021-06548-2

Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis

Claudio Sandroni^*
, Tobias Cronberg
, Mypinder Sekhon

^*Corresponding author

Lund University
University of British Columbia

Research output: Contribution to journal › Article

Abstract

Post-cardiac arrest brain injury (PCABI) is caused by initial ischaemia and subsequent reperfusion of the brain following resuscitation. In those who are admitted to intensive care unit after cardiac arrest, PCABI manifests as coma, and is the main cause of mortality and long-term disability. This review describes the mechanisms of PCABI, its treatment options, its outcomes, and the suggested strategies for outcome prediction.

Original language	English
Pages (from-to)	1393-1414
Number of pages	22
Journal	Intensive Care Medicine
Volume	47
DOIs	https://doi.org/10.1007/s00134-021-06548-2
Publication status	Published - 2021

Keywords

Brain
Brain Injuries
Cardiac arrest
Cardiopulmonary Resuscitation
Coma
EEG
Heart Arrest
Humans
Hypoxia-Ischemia
Prognosis
Prognostication

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10.1007/s00134-021-06548-2

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abstract = "Post-cardiac arrest brain injury (PCABI) is caused by initial ischaemia and subsequent reperfusion of the brain following resuscitation. In those who are admitted to intensive care unit after cardiac arrest, PCABI manifests as coma, and is the main cause of mortality and long-term disability. This review describes the mechanisms of PCABI, its treatment options, its outcomes, and the suggested strategies for outcome prediction.",

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AU - Cronberg, Tobias

AU - Sekhon, Mypinder

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AB - Post-cardiac arrest brain injury (PCABI) is caused by initial ischaemia and subsequent reperfusion of the brain following resuscitation. In those who are admitted to intensive care unit after cardiac arrest, PCABI manifests as coma, and is the main cause of mortality and long-term disability. This review describes the mechanisms of PCABI, its treatment options, its outcomes, and the suggested strategies for outcome prediction.

KW - Brain

KW - Brain Injuries

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KW - Cardiopulmonary Resuscitation

KW - Coma

KW - EEG

KW - Heart Arrest

KW - Humans

KW - Hypoxia-Ischemia

KW - Prognosis

KW - Prognostication

KW - Brain

KW - Brain Injuries

KW - Cardiac arrest

KW - Cardiopulmonary Resuscitation

KW - Coma

KW - EEG

KW - Heart Arrest

KW - Humans

KW - Hypoxia-Ischemia

KW - Prognosis

KW - Prognostication

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JO - Intensive Care Medicine

JF - Intensive Care Medicine

ER -

Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis

Abstract

Keywords

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