Abstract
Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are soluble factors that play a pivotal role in acute and chronic inflammation. TNF is a 17 Kda protein mainly released by monocytes and macrophages and is a common mediator of toxic shock, cachexia and tumor necrosis. IL-1 was first described as a lymphocyte activating factor and it was then discovered that IL-1 has a number of other biological activities and that there are at least two major types of IL-1 (alpha and beta) which bind to the same receptor. Recently it has been shown that TNF and IL-1 beta have an important role in bone resorption
| Translated title of the contribution | [Autom. eng. transl.] [Bone resorption and cytokines: the role of IL-1 beta, TNF and lymphotoxin] |
|---|---|
| Original language | Italian |
| Pages (from-to) | 447-451 |
| Number of pages | 5 |
| Journal | Minerva Stomatologica |
| Volume | 39 |
| Publication status | Published - 1990 |
Keywords
- Bone Resorption
- Humans
- Inflammation
- Interleukin-1
- Lymphotoxin-alpha
- Solubility
- Tumor Necrosis Factor-alpha