Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

Silvia Fare; Serena Bertoldi; Masoumeh Meskinfam; Valentina Spoldi; M. Cristina Tanzi; Ornella Parolini

doi:10.1109/EMBC.2015.7318717

Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

Silvia Fare, Serena Bertoldi, Masoumeh Meskinfam, Valentina Spoldi, M. Cristina Tanzi, Ornella Parolini

Research output: Contribution to journal › Conference article

3 Citations (Scopus)

Abstract

A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration

Original language	English
Pages (from-to)	1753-1756
Number of pages	4
Journal	IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS
Volume	2015
DOIs	https://doi.org/10.1109/EMBC.2015.7318717
Publication status	Published - 2015
Event	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - MILANO -- ITA Duration: 25 Aug 2015 → 29 Aug 2015

Keywords

Biomimetics
Cell Adhesion
Cell Differentiation
Female
Humans
Osteogenesis
Placenta
Polyurethanes
Pregnancy
Surface Properties
Tissue Scaffolds
Weight-Bearing

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10.1109/EMBC.2015.7318717

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title = "Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)",

abstract = "A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration",

keywords = "Biomimetics, Cell Adhesion, Cell Differentiation, Female, Humans, Osteogenesis, Placenta, Polyurethanes, Pregnancy, Surface Properties, Tissue Scaffolds, Weight-Bearing, Biomimetics, Cell Adhesion, Cell Differentiation, Female, Humans, Osteogenesis, Placenta, Polyurethanes, Pregnancy, Surface Properties, Tissue Scaffolds, Weight-Bearing",

author = "Silvia Fare and Serena Bertoldi and Masoumeh Meskinfam and Valentina Spoldi and Tanzi, {M. Cristina} and Ornella Parolini",

year = "2015",

doi = "10.1109/EMBC.2015.7318717",

language = "English",

volume = "2015",

pages = "1753--1756",

journal = "IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS",

issn = "1557-170X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ; Conference date: 25-08-2015 Through 29-08-2015",

}

Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC). / Fare, Silvia; Bertoldi, Serena; Meskinfam, Masoumeh et al.
In: IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS, Vol. 2015, 2015, p. 1753-1756.

Research output: Contribution to journal › Conference article

TY - JOUR

T1 - Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

AU - Fare, Silvia

AU - Bertoldi, Serena

AU - Meskinfam, Masoumeh

AU - Spoldi, Valentina

AU - Tanzi, M. Cristina

AU - Parolini, Ornella

PY - 2015

Y1 - 2015

N2 - A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration

AB - A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration

KW - Biomimetics

KW - Cell Adhesion

KW - Cell Differentiation

KW - Female

KW - Humans

KW - Osteogenesis

KW - Placenta

KW - Polyurethanes

KW - Pregnancy

KW - Surface Properties

KW - Tissue Scaffolds

KW - Weight-Bearing

KW - Biomimetics

KW - Cell Adhesion

KW - Cell Differentiation

KW - Female

KW - Humans

KW - Osteogenesis

KW - Placenta

KW - Polyurethanes

KW - Pregnancy

KW - Surface Properties

KW - Tissue Scaffolds

KW - Weight-Bearing

UR - http://hdl.handle.net/10807/92396

U2 - 10.1109/EMBC.2015.7318717

DO - 10.1109/EMBC.2015.7318717

M3 - Conference article

SN - 1557-170X

VL - 2015

SP - 1753

EP - 1756

JO - IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS

JF - IEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS

T2 - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Y2 - 25 August 2015 through 29 August 2015

ER -

Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

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Keywords

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