Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC)

Ornella Parolini, Silvia Fare, Serena Bertoldi, Masoumeh Meskinfam, Valentina Spoldi, M. Cristina Tanzi

Research output: Contribution to journalConference article

3 Citations (Scopus)

Abstract

A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration
Original languageEnglish
Pages (from-to)1753-1756
Number of pages4
JournalIEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS
Volume2015
DOIs
Publication statusPublished - 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - MILANO -- ITA
Duration: 25 Aug 201529 Aug 2015

Keywords

  • Biomimetics
  • Cell Adhesion
  • Cell Differentiation
  • Female
  • Humans
  • Osteogenesis
  • Placenta
  • Polyurethanes
  • Pregnancy
  • Surface Properties
  • Tissue Scaffolds
  • Weight-Bearing

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