Biomechanical investigation of colorectal cancer cells

Valentina Palmieri; Donatella Lucchetti; Alessandro Maiorana; Massimiliano Papi; Giuseppe Maulucci; Gabriele Ciasca; Maria Svelto; Marco De Spirito; Alessandro Sgambato

doi:10.1063/1.4896161

Biomechanical investigation of colorectal cancer cells

Valentina Palmieri
, Donatella Lucchetti
, Alessandro Maiorana
, Massimiliano Papi^*
, Giuseppe Maulucci
, Gabriele Ciasca
, Maria Svelto
, Marco De Spirito
, Alessandro Sgambato

^*Corresponding author

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force\r\nMicroscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness.\r\nThese two cells populations showed similar adhesion properties while appeared significantly\r\ndifferent in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest\r\nelasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk\r\nand the high-resolution mechanical mapping as a promising diagnostic tool for the identification of\r\nmalignant cells.

Original language	English
Pages (from-to)	N/A-N/A
Number of pages	4
Journal	Applied Physics Letters
Issue number	105
DOIs	https://doi.org/10.1063/1.4896161
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Physics and Astronomy (miscellaneous)

Keywords

cancer cells
colorectal

Access to Document

10.1063/1.4896161

Cite this

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title = "Biomechanical investigation of colorectal cancer cells",

abstract = "The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force\textbackslash{}r\textbackslash{}nMicroscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness.\textbackslash{}r\textbackslash{}nThese two cells populations showed similar adhesion properties while appeared significantly\textbackslash{}r\textbackslash{}ndifferent in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest\textbackslash{}r\textbackslash{}nelasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk\textbackslash{}r\textbackslash{}nand the high-resolution mechanical mapping as a promising diagnostic tool for the identification of\textbackslash{}r\textbackslash{}nmalignant cells.",

keywords = "cancer cells, colorectal, cancer cells, colorectal",

author = "Valentina Palmieri and Donatella Lucchetti and Alessandro Maiorana and Massimiliano Papi and Giuseppe Maulucci and Gabriele Ciasca and Maria Svelto and \{De Spirito\}, Marco and Alessandro Sgambato",

year = "2014",

doi = "10.1063/1.4896161",

language = "English",

pages = "N/A--N/A",

journal = "Applied Physics Letters",

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publisher = "American Institute of Physics",

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TY - JOUR

T1 - Biomechanical investigation of colorectal cancer cells

AU - Palmieri, Valentina

AU - Lucchetti, Donatella

AU - Maiorana, Alessandro

AU - Papi, Massimiliano

AU - Maulucci, Giuseppe

AU - Ciasca, Gabriele

AU - Svelto, Maria

AU - De Spirito, Marco

AU - Sgambato, Alessandro

PY - 2014

Y1 - 2014

N2 - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force\r\nMicroscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness.\r\nThese two cells populations showed similar adhesion properties while appeared significantly\r\ndifferent in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest\r\nelasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk\r\nand the high-resolution mechanical mapping as a promising diagnostic tool for the identification of\r\nmalignant cells.

AB - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force\r\nMicroscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness.\r\nThese two cells populations showed similar adhesion properties while appeared significantly\r\ndifferent in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest\r\nelasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk\r\nand the high-resolution mechanical mapping as a promising diagnostic tool for the identification of\r\nmalignant cells.

KW - cancer cells

KW - colorectal

KW - cancer cells

KW - colorectal

UR - https://publicatt.unicatt.it/handle/10807/66161

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U2 - 10.1063/1.4896161

DO - 10.1063/1.4896161

M3 - Article

SN - 0003-6951

SP - N/A-N/A

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 105

ER -

Biomechanical investigation of colorectal cancer cells

Abstract

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