Biomechanical investigation of colorectal cancer cells

Valentina Palmieri; Donatella Lucchetti; Alessandro Maiorana; Massimiliano Papi; Giuseppe Maulucci; Gabriele Ciasca; Maria Svelto; Marco De Spirito; Alessandro Sgambato

doi:10.1063/1.4896161

Biomechanical investigation of colorectal cancer cells

Valentina Palmieri, Donatella Lucchetti, Alessandro Maiorana, Massimiliano Papi, Giuseppe Maulucci, Gabriele Ciasca, Maria Svelto, Marco De Spirito, Alessandro Sgambato

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

Original language	English
Pages (from-to)	N/A-N/A
Number of pages	4
Journal	Applied Physics Letters
DOIs	https://doi.org/10.1063/1.4896161
Publication status	Published - 2014

Keywords

cancer cells
colorectal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1063/1.4896161

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title = "Biomechanical investigation of colorectal cancer cells",

abstract = "The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.",

keywords = "cancer cells, colorectal, cancer cells, colorectal",

author = "Valentina Palmieri and Donatella Lucchetti and Alessandro Maiorana and Massimiliano Papi and Giuseppe Maulucci and Gabriele Ciasca and Maria Svelto and {De Spirito}, Marco and Alessandro Sgambato",

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doi = "10.1063/1.4896161",

language = "English",

pages = "N/A--N/A",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics:2 Huntington Quadrangle, Suite 1NO1:Melville, NY 11747:(800)344-6902, (631)576-2287, EMAIL: [email protected], INTERNET: http://www.aip.org, Fax: (516)349-9704",

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TY - JOUR

T1 - Biomechanical investigation of colorectal cancer cells

AU - Palmieri, Valentina

AU - Lucchetti, Donatella

AU - Maiorana, Alessandro

AU - Papi, Massimiliano

AU - Maulucci, Giuseppe

AU - Ciasca, Gabriele

AU - Svelto, Maria

AU - De Spirito, Marco

AU - Sgambato, Alessandro

PY - 2014

Y1 - 2014

N2 - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

AB - The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

KW - cancer cells

KW - colorectal

KW - cancer cells

KW - colorectal

UR - http://hdl.handle.net/10807/66161

U2 - 10.1063/1.4896161

DO - 10.1063/1.4896161

M3 - Article

SN - 0003-6951

SP - N/A-N/A

JO - Applied Physics Letters

JF - Applied Physics Letters

ER -

Biomechanical investigation of colorectal cancer cells

Abstract

Keywords

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