Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae)

Michela Panini; Francesco Tozzi; Christoph T Zimmer; Chris Bass; Linda Field; Valerio Borzatta; Emanuele Mazzoni; Graham Moores

doi:10.1002/ps.4553

Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae)

Michela Panini, Francesco Tozzi, Christoph T Zimmer, Chris Bass, Linda Field, Valerio Borzatta, Emanuele Mazzoni, Graham Moores

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

BACKGROUND: Metabolic resistance is an important consideration in the whitefly Bemisia tabaci, where an esterase-based mechanism has been attributed to pyrethroid resistance and over-expression of the cytochrome P450, CYP6CM1, has been correlated to resistance to imidacloprid and other neonicotinoids. RESULTS: In vitro interactions between putative synergists and CYP6CM1, B and Q-type esterases were investigated, and structure-activity relationship analyses allowed the identification of chemical structures capable of acting as inhibitors of esterase and oxidase activities. Specifically, methylenedioxyphenyl (MDP) moieties with a polyether chain were preferable for optimum inhibition of B-type esterase, whilst corresponding dihydrobenzofuran structures were potent for the Q-esterase variation. Potent inhibition of CYP6CM1 resulted from structures which contained an alkynyl chain with a terminal methyl group. CONCLUSIONS: Synergist candidates could be considered for field control of B. tabaci, especially to abrogate neonicotinoid resistance

Original language	English
Pages (from-to)	1873-1882
Number of pages	10
Journal	Pest Management Science
Volume	73
DOIs	https://doi.org/10.1002/ps.4553
Publication status	Published - 2017

Keywords

Bemisia tabaci
synergists

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10.1002/ps.4553

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@article{6c6b61abd7bc428d997d2b92402416ed,

title = "Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae)",

abstract = "BACKGROUND: Metabolic resistance is an important consideration in the whitefly Bemisia tabaci, where an esterase-based mechanism has been attributed to pyrethroid resistance and over-expression of the cytochrome P450, CYP6CM1, has been correlated to resistance to imidacloprid and other neonicotinoids. RESULTS: In vitro interactions between putative synergists and CYP6CM1, B and Q-type esterases were investigated, and structure-activity relationship analyses allowed the identification of chemical structures capable of acting as inhibitors of esterase and oxidase activities. Specifically, methylenedioxyphenyl (MDP) moieties with a polyether chain were preferable for optimum inhibition of B-type esterase, whilst corresponding dihydrobenzofuran structures were potent for the Q-esterase variation. Potent inhibition of CYP6CM1 resulted from structures which contained an alkynyl chain with a terminal methyl group. CONCLUSIONS: Synergist candidates could be considered for field control of B. tabaci, especially to abrogate neonicotinoid resistance",

keywords = "Bemisia tabaci, synergists, Bemisia tabaci, synergists",

author = "Michela Panini and Francesco Tozzi and Zimmer, {Christoph T} and Chris Bass and Linda Field and Valerio Borzatta and Emanuele Mazzoni and Graham Moores",

year = "2017",

doi = "10.1002/ps.4553",

language = "English",

volume = "73",

pages = "1873--1882",

journal = "Pest Management Science",

issn = "1526-4998",

publisher = "John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: [email protected], INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232",

}

Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae). / Panini, Michela; Tozzi, Francesco; Zimmer, Christoph T et al.
In: Pest Management Science, Vol. 73, 2017, p. 1873-1882.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae)

AU - Panini, Michela

AU - Tozzi, Francesco

AU - Zimmer, Christoph T

AU - Bass, Chris

AU - Field, Linda

AU - Borzatta, Valerio

AU - Mazzoni, Emanuele

AU - Moores, Graham

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Metabolic resistance is an important consideration in the whitefly Bemisia tabaci, where an esterase-based mechanism has been attributed to pyrethroid resistance and over-expression of the cytochrome P450, CYP6CM1, has been correlated to resistance to imidacloprid and other neonicotinoids. RESULTS: In vitro interactions between putative synergists and CYP6CM1, B and Q-type esterases were investigated, and structure-activity relationship analyses allowed the identification of chemical structures capable of acting as inhibitors of esterase and oxidase activities. Specifically, methylenedioxyphenyl (MDP) moieties with a polyether chain were preferable for optimum inhibition of B-type esterase, whilst corresponding dihydrobenzofuran structures were potent for the Q-esterase variation. Potent inhibition of CYP6CM1 resulted from structures which contained an alkynyl chain with a terminal methyl group. CONCLUSIONS: Synergist candidates could be considered for field control of B. tabaci, especially to abrogate neonicotinoid resistance

AB - BACKGROUND: Metabolic resistance is an important consideration in the whitefly Bemisia tabaci, where an esterase-based mechanism has been attributed to pyrethroid resistance and over-expression of the cytochrome P450, CYP6CM1, has been correlated to resistance to imidacloprid and other neonicotinoids. RESULTS: In vitro interactions between putative synergists and CYP6CM1, B and Q-type esterases were investigated, and structure-activity relationship analyses allowed the identification of chemical structures capable of acting as inhibitors of esterase and oxidase activities. Specifically, methylenedioxyphenyl (MDP) moieties with a polyether chain were preferable for optimum inhibition of B-type esterase, whilst corresponding dihydrobenzofuran structures were potent for the Q-esterase variation. Potent inhibition of CYP6CM1 resulted from structures which contained an alkynyl chain with a terminal methyl group. CONCLUSIONS: Synergist candidates could be considered for field control of B. tabaci, especially to abrogate neonicotinoid resistance

KW - Bemisia tabaci

KW - synergists

KW - Bemisia tabaci

KW - synergists

UR - http://hdl.handle.net/10807/100329

U2 - 10.1002/ps.4553

DO - 10.1002/ps.4553

M3 - Article

SN - 1526-4998

VL - 73

SP - 1873

EP - 1882

JO - Pest Management Science

JF - Pest Management Science

ER -

Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae)

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