Binding of steroids to blastokinin

Nicola Garcea, Sebastiano Campo, Alessandro Caruso, Adriano Bompiani, Liborio Milano

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The authors studied the binding of steroids with Blastokinin (BKN). They confirm that progesterone is the steroid that has a greater affinity for BKN than estradiol or testosterone; the latter is hardly bound to the protein at all. They also show that the presence of estradiol interferes with the formation phase of the BKN-progesterone complex, while testosterone does not. When the BKN-progesterone complex is already formed, a release of the progesterone occurs only when there is a double concentration of estradiol. The biological importance of this phenomenon is briefly discussed.
Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalInternational Journal of Fertility
Volume19
Publication statusPublished - 1974

Keywords

  • Androgens
  • Animals
  • Animals, Laboratory
  • Binding Sites
  • Biology
  • Clinical Research
  • Endocrine System
  • Estradiol
  • Estradiol--analysis
  • Estrogens
  • Female
  • Hormone Receptors
  • Hormones
  • In Vitro
  • Kinins
  • Membrane Proteins
  • Physiology
  • Progestational Hormones
  • Progesterone
  • Progesterone--analysis
  • Protein Binding
  • Rabbits
  • Research Methodology
  • Testosterone
  • Testosterone--analysis
  • Uterus

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