Bilateral 5 Hz transcranial alternating current stimulation on frontooral areas modulates resting-state EEG

Maurizio Gorgoni, Paolo Maria Rossini, Aurora D'Atri, Claudia Romano, Serena Scarpelli, Valentina Alfonsi, Michele Ferrara, Fabio Ferlazzo, Luigi De Gennaro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rhythmic non-invasive brain stimulations are promising tools to modulate brain activity by entraining neural oscillations in specific cortical networks. The aim of the study was to assess the possibility to influence the neural circuits of the wake-sleep transition in awake subjects via a bilateral transcranial alternating current stimulation at 5 Hz (θ-tACS) on frontooral areas. 25 healthy volunteers participated in two within-subject sessions (θ-tACS and sham), one week apart and in counterbalanced order. We assessed the stimulation effects on cortical EEG activity (28 derivations) and self-reported sleepiness (Karolinska Sleepiness Scale). θ-tACS induced significant increases of the theta activity in temporo-parieto-occipital areas and centro-frontal increases in the alpha activity compared to sham but failed to induce any online effect on sleepiness. Since the total energy delivered in the sham condition was much less than in the active θ-tACS, the current data are unable to isolate the specific effect of entrained theta oscillatory activity per se on sleepiness scores. On this basis, we concluded that θ-tACS modulated theta and alpha EEG activity with a topography consistent with high sleep pressure conditions. However, no causal relation can be traced on the basis of the current results between these rhythms and changes on sleepiness.
Original languageEnglish
Pages (from-to)15672-15683
Number of pages12
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 2017

Keywords

  • Multidisciplinary

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