beta-Carotene and alpha-tocopherol are synergistic antioxidants.

Paola Palozza, Ni Krinsky

Research output: Contribution to journalArticlepeer-review


The possibility of a cooperative interaction between fat-soluble antioxidants is examined in a membrane model. A combination of beta-carotene and alpha-tocopherol results in an inhibition of lipid peroxidation significantly greater than the sum of the individual inhibitions. Our data provide the first evidence that beta-carotene can act synergistically with alpha-tocopherol as an effective radical-trapping antioxidant in membranes.
Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalArchives of Biochemistry and Biophysics
Publication statusPublished - 1992
Externally publishedYes


  • alpha-tocopherol
  • beta-carotene


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