BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

Gianfranco Spalletta; Dw Morris; F Angelucci; Ia Rubino; Ilaria Spoletini; Pietro Bria; Giovanni Martinotti; A Siracusano; G Bonaviri; S Bernardini; C Caltagirone; P Bossù; G Donohoe; M Gill; Ap Corvin

doi:10.1016/j.eurpsy.2009.10.008

BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

Gianfranco Spalletta, Dw Morris, F Angelucci, Ia Rubino, Ilaria Spoletini, Pietro Bria, Giovanni Martinotti, A Siracusano, G Bonaviri, S Bernardini, C Caltagirone, P Bossù, G Donohoe, M Gill, Ap Corvin

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

Original language	English
Pages (from-to)	311-313
Number of pages	3
Journal	European psychiatry : the journal of the Association of European Psychiatrists
Volume	25
DOIs	https://doi.org/10.1016/j.eurpsy.2009.10.008
Publication status	Published - 2010
Externally published	Yes

Keywords

Adult
Aggression
Brain-Derived Neurotrophic Factor
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Methionine
Middle Aged
Polymorphism, Single Nucleotide
Schizophrenia
Schizophrenic Psychology
Valine

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10.1016/j.eurpsy.2009.10.008

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Spalletta, G., Morris, D., Angelucci, F., Rubino, I., Spoletini, I., Bria, P., Martinotti, G., Siracusano, A., Bonaviri, G., Bernardini, S., Caltagirone, C., Bossù, P., Donohoe, G., Gill, M., & Corvin, A. (2010). BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia. European psychiatry : the journal of the Association of European Psychiatrists, 25, 311-313. https://doi.org/10.1016/j.eurpsy.2009.10.008

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abstract = "Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.",

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author = "Gianfranco Spalletta and Dw Morris and F Angelucci and Ia Rubino and Ilaria Spoletini and Pietro Bria and Giovanni Martinotti and A Siracusano and G Bonaviri and S Bernardini and C Caltagirone and P Boss{\`u} and G Donohoe and M Gill and Ap Corvin",

year = "2010",

doi = "10.1016/j.eurpsy.2009.10.008",

language = "English",

volume = "25",

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Spalletta, G, Morris, D, Angelucci, F, Rubino, I, Spoletini, I, Bria, P, Martinotti, G, Siracusano, A, Bonaviri, G, Bernardini, S, Caltagirone, C, Bossù, P, Donohoe, G, Gill, M & Corvin, A 2010, 'BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia', European psychiatry : the journal of the Association of European Psychiatrists, vol. 25, pp. 311-313. https://doi.org/10.1016/j.eurpsy.2009.10.008

TY - JOUR

T1 - BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

AU - Spalletta, Gianfranco

AU - Morris, Dw

AU - Angelucci, F

AU - Rubino, Ia

AU - Spoletini, Ilaria

AU - Bria, Pietro

AU - Martinotti, Giovanni

AU - Siracusano, A

AU - Bonaviri, G

AU - Bernardini, S

AU - Caltagirone, C

AU - Bossù, P

AU - Donohoe, G

AU - Gill, M

AU - Corvin, Ap

PY - 2010

Y1 - 2010

N2 - Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

AB - Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

KW - Adult

KW - Aggression

KW - Brain-Derived Neurotrophic Factor

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Methionine

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Schizophrenia

KW - Schizophrenic Psychology

KW - Valine

KW - Adult

KW - Aggression

KW - Brain-Derived Neurotrophic Factor

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Methionine

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Schizophrenia

KW - Schizophrenic Psychology

KW - Valine

UR - http://hdl.handle.net/10807/56956

U2 - 10.1016/j.eurpsy.2009.10.008

DO - 10.1016/j.eurpsy.2009.10.008

M3 - Article

VL - 25

SP - 311

EP - 313

JO - European psychiatry : the journal of the Association of European Psychiatrists

JF - European psychiatry : the journal of the Association of European Psychiatrists

ER -

BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

Abstract

Keywords

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