BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

Gianfranco Spalletta, Dw Morris, F Angelucci, Ia Rubino, Ilaria Spoletini, Pietro Bria, Giovanni Martinotti, A Siracusano, G Bonaviri, S Bernardini, C Caltagirone, P Bossù, G Donohoe, M Gill, Ap Corvin

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61 Citations (Scopus)


Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.
Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalEuropean psychiatry : the journal of the Association of European Psychiatrists
Publication statusPublished - 2010
Externally publishedYes


  • Adult
  • Aggression
  • Brain-Derived Neurotrophic Factor
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Methionine
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Schizophrenia
  • Schizophrenic Psychology
  • Valine


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