Baclofen in the treatment of persistent hiccup: a case series.

Antonio Mirijello; Giovanni Addolorato; Cristina D'Angelo; Anna Ferrulli; Gabriele Angelo Vassallo; Mariangela Antonelli; Lorenzo Leggio; Raffaele Landolfi

doi:10.1111/ijcp.12184

Baclofen in the treatment of persistent hiccup: a case series.

Antonio Mirijello
, Giovanni Addolorato
, Cristina D'Angelo
, Anna Ferrulli
, Gabriele Angelo Vassallo
, Mariangela Antonelli
, Lorenzo Leggio
, Raffaele Landolfi

Research output: Contribution to journal › Article

20 Citations (SciVal)

Abstract

Abstract BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.

Original language	English
Pages (from-to)	918-921
Number of pages	4
Journal	internal journal of clinical practice
DOIs	https://doi.org/10.1111/ijcp.12184
Publication status	Published - 2013

Keywords

baclofen
treatment

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10.1111/ijcp.12184

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title = "Baclofen in the treatment of persistent hiccup: a case series.",

abstract = "Abstract BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.",

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author = "Antonio Mirijello and Giovanni Addolorato and Cristina D'Angelo and Anna Ferrulli and Vassallo, \{Gabriele Angelo\} and Mariangela Antonelli and Lorenzo Leggio and Raffaele Landolfi",

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journal = "internal journal of clinical practice",

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T1 - Baclofen in the treatment of persistent hiccup: a case series.

AU - Mirijello, Antonio

AU - Addolorato, Giovanni

AU - D'Angelo, Cristina

AU - Ferrulli, Anna

AU - Vassallo, Gabriele Angelo

AU - Antonelli, Mariangela

AU - Leggio, Lorenzo

AU - Landolfi, Raffaele

PY - 2013

Y1 - 2013

N2 - Abstract BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.

AB - Abstract BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.

KW - baclofen

KW - treatment

KW - baclofen

KW - treatment

UR - http://hdl.handle.net/10807/52842

U2 - 10.1111/ijcp.12184

DO - 10.1111/ijcp.12184

M3 - Article

SP - 918

EP - 921

JO - internal journal of clinical practice

JF - internal journal of clinical practice

ER -

Baclofen in the treatment of persistent hiccup: a case series.

Abstract

Keywords

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