Autoimmunity in obstetrics and autoimmune diseases in pregnancy

Sara De Carolis, Antonio Lanzone, Francesca Rizzo, Silvia Salvi, Sara Tabacco, Cristina Garufi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Autoimmune diseases (AIDs) are associated with strong female preponderance and often present before or during the reproductive years; consequently, pregnancy and breastfeeding are topics of major interest for these patients. AIDs show different responses to pregnancy: some ameliorate, while others remain unchanged, and several AIDs aggravate. The response of the AIDs to the hormonal and immunological alterations of pregnancy reflects the different pathophysiology of each disease. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are associated with multiple autoantibodies, multiorgan involvement, more aggressive therapy, and increased impact on pregnancy outcome. For the management of pregnancy in patients with SLE and/or APS, it is important to individuate the correct risk profile for each woman and timing for treatment. The optimal timing for starting or modulating treatment is at preconception assessment to influence the placentation. In this chapter, we discuss the management of pregnancy in patients with AIDs.
Original languageEnglish
Pages (from-to)66-76
Number of pages11
JournalBAILLIERE'S BEST PRACTICE & RESEARCH. CLINICAL OBSTETRICS & GYNAECOLOGY
Volume60
DOIs
Publication statusPublished - 2019

Keywords

  • APS
  • Antiphospholipid Syndrome
  • Autoimmune Diseases
  • Autoimmunity
  • Female
  • Fetal loss
  • Humans
  • IUGR
  • Lupus Erythematosus, Systemic
  • Obstetrics
  • Pregnancy
  • Pregnancy Complications
  • Pregnancy Outcome
  • SLE

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