Attenuation of aortic banding-induced cardiac hypertrophy by propranolol is independent of beta-adrenoceptor blockade

Alessandro Vergari, G Marano, S Palazzesi, Antonello Fadda, Au Ferrari

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Racemic propranolol attenuates cardiac hypertrophy secondary to abdominal aortic banding-induced pressure overload by a mechanism independent of its effect on cardiac work load. This was only observed, however, using doses of propranolol that were much higher than those needed to induce beta-adrenoceptor blockade. Thus, the question remains as to whether the antihypertrophic effect of propranolol depends on its ability to antagonize cardiac beta-adrenoceptor-mediated action (positive chronotropic effect, trophic effect) or on beta-adrenoceptor-independent action.
Original languageEnglish
Pages (from-to)763-769
Number of pages7
JournalJOURNAL OF HYPERTENSION
Volume20
Publication statusPublished - 2002

Keywords

  • Adrenergic beta-Antagonists
  • Animals
  • Aorta, Abdominal
  • Disopyramide
  • Hypertrophy, Left Ventricular
  • Male
  • Propranolol
  • Rats
  • Rats, Inbred WKY
  • Stereoisomerism
  • Timolol

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