Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism

Ilaria Zanotti; Margherita Dall'Asta; Pedro Mena; Laura Mele; Renato Bruni; Sumantra Ray; Daniele Del Rio

doi:10.1039/c4fo00670d

Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism

Ilaria Zanotti, Margherita Dall'Asta, Pedro Mena, Laura Mele, Renato Bruni, Sumantra Ray, Daniele Del Rio

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Abstract

Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly) phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly) phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly) phenols are critically discussed.

Original language	English
Pages (from-to)	13-31
Number of pages	19
Journal	FOOD & FUNCTION
Volume	6
DOIs	https://doi.org/10.1039/c4fo00670d
Publication status	Published - 2015

Keywords

cholesterol
polyphenols

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10.1039/c4fo00670d

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title = "Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism",

abstract = "Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly) phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly) phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly) phenols are critically discussed.",

keywords = "cholesterol, polyphenols, cholesterol, polyphenols",

author = "Ilaria Zanotti and Margherita Dall'Asta and Pedro Mena and Laura Mele and Renato Bruni and Sumantra Ray and {Del Rio}, Daniele",

year = "2015",

doi = "10.1039/c4fo00670d",

language = "English",

volume = "6",

pages = "13--31",

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T1 - Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism

AU - Zanotti, Ilaria

AU - Dall'Asta, Margherita

AU - Mena, Pedro

AU - Mele, Laura

AU - Bruni, Renato

AU - Ray, Sumantra

AU - Del Rio, Daniele

PY - 2015

Y1 - 2015

N2 - Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly) phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly) phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly) phenols are critically discussed.

AB - Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly) phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly) phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly) phenols are critically discussed.

KW - cholesterol

KW - polyphenols

KW - cholesterol

KW - polyphenols

UR - http://hdl.handle.net/10807/163884

U2 - 10.1039/c4fo00670d

DO - 10.1039/c4fo00670d

M3 - Article

SN - 2042-6496

VL - 6

SP - 13

EP - 31

JO - FOOD & FUNCTION

JF - FOOD & FUNCTION

ER -

Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism

Abstract

Keywords

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