Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients

Maurizio Martini, Luigi Maria Larocca, Giovambattista Pani, Anna Maria Ferrara, Manuela Giachelia, Emiliano Panieri, Tommaso Galeotti, Katherine Siminovitch

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).
Original languageEnglish
Pages (from-to)439-448
Number of pages10
JournalInflammatory Bowel Diseases
Volume18
DOIs
Publication statusPublished - 2012

Keywords

  • Caco-2 Cells
  • Colitis, Ulcerative
  • OCTN1-2

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