Association of metabolic syndrome with falls in patients with Parkinson's disease

Anna Rita Bentivoglio, Roberto Bernabei, Giuseppe Zuccala', Alice Laudisio, Maria Rita Lo Monaco, Davide Liborio Vetrano, Maria Stella Pisciotta

Research output: Contribution to journalArticle

6 Citations (Scopus)


BACKGROUND & AIMS: Falls are a major threat for patients with Parkinson's disease, as they are associated with higher risk of morbidity, loss of functional ability, institutionalization, and mortality. Metabolic syndrome (MetS) is associated with poorer physical performance in middle age, but its impact in the older and frailer subjects is unclear. The present study aimed at assessing the association of MetS with falls in patients with Parkinson's disease. METHODS: We analyzed data of 194 elderly with Parkinson's disease attending a geriatric Day Hospital. History of falls that occurred over the last year, as well as and the number of falls, were recorded. Metabolic syndrome was diagnosed according to the National Cholesterol Education Program's ATP-III criteria. RESULTS: Falls were reported by 91 participants (47%). Logistic regression analysis showed that MetS was associated with reduced occurrence of falls (OR = .26; 95% CI = .10-.69; P = .007). Also, among participants who fell, Poisson regression indicated that MetS predicted a reduced number of falls (IRR = .43; 95% CI = .20-.89; P = .024). CONCLUSIONS: In our population MetS was associated with reduced probability of falls; among subjects who fell, MetS was associated with a reduced number of falls. Dedicated studies are needed to better understand the subsystems involved, as well as the therapeutic implications of such an association.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalClinical Nutrition
Publication statusPublished - 2016


  • Elderly
  • Falls
  • Metabolic syndrome
  • Parkinson's disease
  • Reverse epidemiology


Dive into the research topics of 'Association of metabolic syndrome with falls in patients with Parkinson's disease'. Together they form a unique fingerprint.

Cite this