Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium

Michele Sassano; Martina Taborelli; Stefania Boccia; Gabriella Cadoni; Carlo La Vecchia; Werner Garavello; Philip Lazarus; Yuan-Chin Amy Lee; Mia Hashibe; Paolo Boffetta

doi:10.1002/hed.27638

Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium

Michele Sassano, Martina Taborelli, Stefania Boccia^*, Gabriella Cadoni, Carlo La Vecchia, Werner Garavello, Philip Lazarus, Yuan-Chin Amy Lee, Mia Hashibe, Paolo Boffetta

^*Corresponding author

Research output: Contribution to journal › Article

Abstract

Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium.Methods: Four case-control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian-Laird random-effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials.Results: Aspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer.Conclusions: This study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.

Original language	English
Pages (from-to)	926-935
Number of pages	10
Journal	HEAD & NECK
Volume	46
DOIs	https://doi.org/10.1002/hed.27638
Publication status	Published - 2024

Keywords

aspirin
case-control
consortia
head and neck cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.27638

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@article{dcbd8cd80f424a34908e34dbeef81e81,

title = "Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium",

abstract = "Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium.Methods: Four case-control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian-Laird random-effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials.Results: Aspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer.Conclusions: This study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.",

keywords = "aspirin, case-control, consortia, head and neck cancer, aspirin, case-control, consortia, head and neck cancer",

author = "Michele Sassano and Martina Taborelli and Stefania Boccia and Gabriella Cadoni and {La Vecchia}, Carlo and Werner Garavello and Philip Lazarus and Lee, {Yuan-Chin Amy} and Mia Hashibe and Paolo Boffetta",

year = "2024",

doi = "10.1002/hed.27638",

language = "English",

volume = "46",

pages = "926--935",

journal = "HEAD & NECK",

issn = "1043-3074",

publisher = "[New York, NY] : Wiley Periodicals, Inc., c1989-",

}

TY - JOUR

T1 - Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium

AU - Sassano, Michele

AU - Taborelli, Martina

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - La Vecchia, Carlo

AU - Garavello, Werner

AU - Lazarus, Philip

AU - Lee, Yuan-Chin Amy

AU - Hashibe, Mia

AU - Boffetta, Paolo

PY - 2024

Y1 - 2024

N2 - Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium.Methods: Four case-control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian-Laird random-effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials.Results: Aspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer.Conclusions: This study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.

AB - Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium.Methods: Four case-control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian-Laird random-effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials.Results: Aspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer.Conclusions: This study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.

KW - aspirin

KW - case-control

KW - consortia

KW - head and neck cancer

KW - aspirin

KW - case-control

KW - consortia

KW - head and neck cancer

UR - http://hdl.handle.net/10807/277916

U2 - 10.1002/hed.27638

DO - 10.1002/hed.27638

M3 - Article

SN - 1043-3074

VL - 46

SP - 926

EP - 935

JO - HEAD & NECK

JF - HEAD & NECK

ER -

Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium

Abstract

Keywords

UN SDGs

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