Applications of the Amniotic Membrane in Vitreoretinal Surgery

Tomaso Caporossi, Ruggero Tartaro, Daniela Bacherini, Bianca Pacini, Lorenzo De Angelis, Lorenzo Governatori, Laura Di Leo, Leandro Oliverio, Stanislao Rizzo

Research output: Contribution to journalArticle


Recently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders, such as macular holes that failed to close and retinal tears. The hAM has demonstrated the induction of a recovery process of the external retinal layers involving the external limiting membrane (ELM) and the ellipsoid zone (EZ). After that, the application of the hAM for retinal pathologies was extended to large macular tears, high myopic retinal detachment associated with MH, paravascular tears, serous macular detachment associated with optic pit, complicated retinal detachment and advanced age-related macular degeneration (AMD). The hAM has shown a potential in repairing retinal tissue through a regeneration process. This review aims to highlight the use of the hAM in various vitreo-retinal surgical fields, and to confront it with other cutting-edge surgical techniques used to treat challenging vitreo-retinal pathologies.
Original languageEnglish
Pages (from-to)2675-2686
Number of pages12
JournalJournal of Clinical Medicine
Publication statusPublished - 2020


  • age related macular degeneration
  • amniotic membrane
  • macular hole
  • optic pit maculopathy
  • retinal detachment
  • vitrectomy
  • vitreoretinal surgery


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