Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E.

Anna Rita Fetoni, Bruno Sergi, Giuseppe Tringali, Roberto Piacentini, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Diana Troiani

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Idebenone, a synthetic analogue of coenzyme Q, attenuates noise-induced hearing loss by virtue of its antioxidant properties. This study involves a guinea pig model of acoustic trauma where the effectiveness of idebenone is analyzed in comparison with Vitamin E (alpha-tocopherol) that exhibits a potent antioxidant activity in the inner ear. Idebenone and vitamin E were injected intraperitoneally 1 h before noise exposure and once daily for three days; functional and morphological studies were then carried out, respectively, by auditory brainstem responses evaluation, scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay identification of missing and apoptotic cells was also performed. The results showed that the protective effects of idebenone and vitamin E were not additive implying that the two antioxidants may share competitive mechanisms.
Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalNeuroReport
Publication statusPublished - 2008

Keywords

  • Antioxidant
  • Idibenone
  • Neuroprotection

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