Antioxidant effect of ferulic acid in isolated membranes and intact cells: synergistic interactions with alpha-tocopherol, beta-carotene, and ascorbic acid.

Simona Serini, Gabriella Calviello, Fiorella Di Nicuolo, Leonardo Celleno, Paola Palozza, Sonia Trombino, S Andò, N Picci

Research output: Contribution to journalArticlepeer-review

Abstract

Although an antioxidant mechanism has been involved in the beneficial effects of ferulic acid in human diseases, there are few reports on the antioxidant properties of this compound in isolated membranes and intact cells. Here, we evaluated the ability of ferulic acid in inhibiting lipid peroxidation in rat liver microsomal membranes and reactive oxygen species production in NIH-3T3 fibroblasts, induced by both tert-BOOH and AAPH. We also compared its antioxidant efficiency with that of other antioxidants, such as alpha-tocopherol, beta-carotene, and ascorbic acid, added alone or in combination. Ferulic acid acted as a potent antioxidant in our models, being more effective in protecting from tert-BOOH than from AAPH. Moreover, the compound was the most effective among the antioxidants tested. Synergistic interactions were observed when the compound was used in combination with the other antioxidants, suggesting that they can cooperate in preserving physiological integrity of cells exposed to free radicals.
Original languageEnglish
Pages (from-to)2411-2420
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Publication statusPublished - 2004

Keywords

  • Antioxidant
  • Feruli acid
  • alpha-tocopherol
  • ascorbic acid
  • intact cells
  • membranes

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