Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Nicoletta Di Simone; M Silano; Roberta Castellani; Fiorella Di Nicuolo; Mc D'Alessio; Francesco Franceschi; Alessandra Tritarelli; Antonio Maria Leone; Chiara Tersigni; Giovanni Battista Gasbarrini; Ng Silveri; Alessandro Caruso; Antonio Gasbarrini

doi:10.1038/ajg.2010.233

Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Nicoletta Di Simone
, M Silano
, Roberta Castellani
, Fiorella Di Nicuolo
, Mc D'Alessio
, Francesco Franceschi
, Alessandra Tritarelli
, Antonio Maria Leone
, Chiara Tersigni
, Giovanni Battista Gasbarrini
, Ng Silveri
, Alessandro Caruso
, Antonio Gasbarrini^*

^*Corresponding author

Research output: Contribution to journal › Article

47 Citations (Scopus)

Abstract

The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.

Original language	English
Pages (from-to)	2254-2261
Number of pages	8
Journal	THE AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume	105
Issue number	10
DOIs	https://doi.org/10.1038/ajg.2010.233
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

Keywords

Anti-Idiotypic
Antibodies
Apoptosis
Celiac Disease
Cells
Cultured
Female
Flow Cytometry
Humans
In Situ Nick-End Labeling
Placenta
Pregnancy
Transglutaminases
Trophoblasts

Access to Document

10.1038/ajg.2010.233

Cite this

Di Simone, N., Silano, M., Castellani, R., Di Nicuolo, F., D'Alessio, M., Franceschi, F., Tritarelli, A., Leone, A. M., Tersigni, C., Gasbarrini, G. B., Silveri, N., Caruso, A., & Gasbarrini, A. (2010). Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro. THE AMERICAN JOURNAL OF GASTROENTEROLOGY, 105(10), 2254-2261. https://doi.org/10.1038/ajg.2010.233

@article{c92febb6a1dd4a40ab5c4d57805202af,

title = "Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro",

abstract = "The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.",

keywords = "Anti-Idiotypic, Antibodies, Apoptosis, Celiac Disease, Cells, Cultured, Female, Flow Cytometry, Humans, In Situ Nick-End Labeling, Placenta, Pregnancy, Transglutaminases, Trophoblasts, Anti-Idiotypic, Antibodies, Apoptosis, Celiac Disease, Cells, Cultured, Female, Flow Cytometry, Humans, In Situ Nick-End Labeling, Placenta, Pregnancy, Transglutaminases, Trophoblasts",

author = "\{Di Simone\}, Nicoletta and M Silano and Roberta Castellani and \{Di Nicuolo\}, Fiorella and Mc D'Alessio and Francesco Franceschi and Alessandra Tritarelli and Leone, \{Antonio Maria\} and Chiara Tersigni and Gasbarrini, \{Giovanni Battista\} and Ng Silveri and Alessandro Caruso and Antonio Gasbarrini",

year = "2010",

doi = "10.1038/ajg.2010.233",

language = "English",

volume = "105",

pages = "2254--2261",

journal = "THE AMERICAN JOURNAL OF GASTROENTEROLOGY",

issn = "0002-9270",

publisher = "New York, NY: Elsevier Science Incorporated -New York: National Gastroenterological Association",

number = "10",

}

Di Simone, N, Silano, M, Castellani, R, Di Nicuolo, F, D'Alessio, M, Franceschi, F, Tritarelli, A, Leone, AM, Tersigni, C, Gasbarrini, GB, Silveri, N, Caruso, A & Gasbarrini, A 2010, 'Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro', THE AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 105, no. 10, pp. 2254-2261. https://doi.org/10.1038/ajg.2010.233

TY - JOUR

T1 - Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

AU - Di Simone, Nicoletta

AU - Silano, M

AU - Castellani, Roberta

AU - Di Nicuolo, Fiorella

AU - D'Alessio, Mc

AU - Franceschi, Francesco

AU - Tritarelli, Alessandra

AU - Leone, Antonio Maria

AU - Tersigni, Chiara

AU - Gasbarrini, Giovanni Battista

AU - Silveri, Ng

AU - Caruso, Alessandro

AU - Gasbarrini, Antonio

PY - 2010

Y1 - 2010

N2 - The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.

AB - The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.

KW - Anti-Idiotypic

KW - Antibodies

KW - Apoptosis

KW - Celiac Disease

KW - Cells

KW - Cultured

KW - Female

KW - Flow Cytometry

KW - Humans

KW - In Situ Nick-End Labeling

KW - Placenta

KW - Pregnancy

KW - Transglutaminases

KW - Trophoblasts

KW - Anti-Idiotypic

KW - Antibodies

KW - Apoptosis

KW - Celiac Disease

KW - Cells

KW - Cultured

KW - Female

KW - Flow Cytometry

KW - Humans

KW - In Situ Nick-End Labeling

KW - Placenta

KW - Pregnancy

KW - Transglutaminases

KW - Trophoblasts

UR - https://publicatt.unicatt.it/handle/10807/21486

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=77957837224&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957837224&origin=inward

U2 - 10.1038/ajg.2010.233

DO - 10.1038/ajg.2010.233

M3 - Article

SN - 0002-9270

VL - 105

SP - 2254

EP - 2261

JO - THE AMERICAN JOURNAL OF GASTROENTEROLOGY

JF - THE AMERICAN JOURNAL OF GASTROENTEROLOGY

IS - 10

ER -

Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this