Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Francesco Franceschi, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Nicoletta Di Simone, Antonio Maria Leone, Chiara Tersigni, Marco Silano

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro.
Original languageEnglish
Pages (from-to)2254-2261
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume105
DOIs
Publication statusPublished - 2010

Keywords

  • Antibodies, Anti-Idiotypic
  • Apoptosis
  • Celiac Disease
  • Cells, Cultured
  • Female
  • Flow Cytometry
  • Humans
  • In Situ Nick-End Labeling
  • Placenta
  • Pregnancy
  • Transglutaminases
  • Trophoblasts

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