Anti-amyloid-β protein agents for the treatment of Alzheimer’s disease: an update on emerging drugs

Antonio Daniele, Antonio Liguori, Alberto Bellomo, Madia Lozupone, Vincenzo Solfrizzi, Francesca D’Urso, Ilaria Di Gioia, Rodolfo Sardone, Vittorio Dibello, Roberta Stallone, Angelo Liguori, Chiara Ciritella, Antonello Bellomo, Davide Seripa, Francesco Panza

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Currently available Alzheimer’s disease (AD) therapeutics are only symptomatic, targeting cholinergic and glutamatergic neurotransmissions. Several putative disease-modifying drugs in late-stage clinical development target amyloid-β (Aβ) peptide and tau protein, the principal neurophatological hallmarks of the disease. Areas covered: Phase III randomized clinical trials of anti-Aβ drugs for AD treatment were searched in US and EU clinical trial registries and principal biomedical databases until May 2020. Expert opinion: At present, compounds in Phase III clinical development for AD include four  anti-Ab monoclonal antibodies (solanezumab, gantenerumab, aducanumab, BAN2401), the combination of cromolyn sodium and ibuprofen (ALZT-OP1), and two small molecules (levetiracetam, GV-971). These drugs are mainly being tested in subjects during early AD phases or at preclinical stage of familial AD or even in asymptomatic subjects at high risk of developing AD. The actual results support the hypothesis that elevated Aβ represents an early stage in the AD continuum and demonstrate the feasibility of enrolling these high-risk participants in secondary prevention trials to slow cognitive decline during the AD preclinical stages. However, a series of clinical failures may question further development of Aβ-targeting drugs and the findings from current ongoing Phase III trials will hopefully give light to this critical issue.
Original languageEnglish
Pages (from-to)319-335
Number of pages17
JournalExpert Opinion on Emerging Drugs
Volume25
DOIs
Publication statusPublished - 2020

Keywords

  • ALZT-OP1
  • Alzheimer’s disease
  • BAN2401
  • GV-971
  • Monoclonal antibodies
  • aducanumab
  • cognitive disorders
  • gantenerumab
  • levetiracetam
  • solanezumab

Fingerprint

Dive into the research topics of 'Anti-amyloid-β protein agents for the treatment of Alzheimer’s disease: an update on emerging drugs'. Together they form a unique fingerprint.

Cite this