Anti-AChR-negative myasthenia gravis: clinical and immunological features

Amelia Evoli Stampanoni-B; Emanuela Bartoccioni; Anna Paola Batocchi; Flavia Scuderi; Pietro Attilio Tonali

Anti-AChR-negative myasthenia gravis: clinical and immunological features

Amelia Evoli Stampanoni-B, Emanuela Bartoccioni, Anna Paola Batocchi, Flavia Scuderi, Pietro Attilio Tonali

Università Cattolica del Sacro Cuore

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Abstract

The clinical and immunological characteristics of myasthenia gravis (MG) patients without detectable anti-Acetylcholine Receptor (anti-AChR) antibody were studied. Sixty anti-AChR negative MG patients were compared with 287 anti-AChR positive cases. Significant differences were found with respect to the sex incidence, the disease severity and the thymic pathology, while the age at the onset of the disease, the presence of other auto-antibodies and the efficacy of medical treatments were similar in the two groups of patients. Anti-AChR-negative MG could have pathogenetic mechanisms different from the antibody-positive disease.

Original language	English
Pages (from-to)	104-109
Number of pages	6
Journal	CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE
Volume	12
Publication status	Published - 1989

Keywords

Anti-AChR-negative
Myasthenia Gravis

Cite this

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title = "Anti-AChR-negative myasthenia gravis: clinical and immunological features",

abstract = "The clinical and immunological characteristics of myasthenia gravis (MG) patients without detectable anti-Acetylcholine Receptor (anti-AChR) antibody were studied. Sixty anti-AChR negative MG patients were compared with 287 anti-AChR positive cases. Significant differences were found with respect to the sex incidence, the disease severity and the thymic pathology, while the age at the onset of the disease, the presence of other auto-antibodies and the efficacy of medical treatments were similar in the two groups of patients. Anti-AChR-negative MG could have pathogenetic mechanisms different from the antibody-positive disease.",

keywords = "Anti-AChR-negative, Myasthenia Gravis, Anti-AChR-negative, Myasthenia Gravis",

author = "\{Evoli Stampanoni-B\}, Amelia and Emanuela Bartoccioni and Batocchi, \{Anna Paola\} and Flavia Scuderi and Tonali, \{Pietro Attilio\}",

year = "1989",

language = "English",

volume = "12",

pages = "104--109",

journal = "CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE",

issn = "0147-958X",

publisher = "Canadian Medical Association:1867 Alta Vista Drive, Ottawa Ontario K1G 5W8 Canada:(888)855-2555, (613)731-8610, EMAIL: [email protected], INTERNET: http://www.cma.ca, Fax: (613)236-8864",

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TY - JOUR

T1 - Anti-AChR-negative myasthenia gravis: clinical and immunological features

AU - Evoli Stampanoni-B, Amelia

AU - Bartoccioni, Emanuela

AU - Batocchi, Anna Paola

AU - Scuderi, Flavia

AU - Tonali, Pietro Attilio

PY - 1989

Y1 - 1989

N2 - The clinical and immunological characteristics of myasthenia gravis (MG) patients without detectable anti-Acetylcholine Receptor (anti-AChR) antibody were studied. Sixty anti-AChR negative MG patients were compared with 287 anti-AChR positive cases. Significant differences were found with respect to the sex incidence, the disease severity and the thymic pathology, while the age at the onset of the disease, the presence of other auto-antibodies and the efficacy of medical treatments were similar in the two groups of patients. Anti-AChR-negative MG could have pathogenetic mechanisms different from the antibody-positive disease.

AB - The clinical and immunological characteristics of myasthenia gravis (MG) patients without detectable anti-Acetylcholine Receptor (anti-AChR) antibody were studied. Sixty anti-AChR negative MG patients were compared with 287 anti-AChR positive cases. Significant differences were found with respect to the sex incidence, the disease severity and the thymic pathology, while the age at the onset of the disease, the presence of other auto-antibodies and the efficacy of medical treatments were similar in the two groups of patients. Anti-AChR-negative MG could have pathogenetic mechanisms different from the antibody-positive disease.

KW - Anti-AChR-negative

KW - Myasthenia Gravis

KW - Anti-AChR-negative

KW - Myasthenia Gravis

UR - http://hdl.handle.net/10807/18626

M3 - Article

SN - 0147-958X

VL - 12

SP - 104

EP - 109

JO - CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE

JF - CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE

ER -

Anti-AChR-negative myasthenia gravis: clinical and immunological features

Abstract

Keywords

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