Angiosarcoma of an Arteriovenous Fistula for Hemodialysis in a Kidney Transplant Recipient Affected by Lowe's Syndrome

Giuseppe Grandaliano, Pietro Manuel Ferraro, Viola D'Ambrosio, Patrizia Silvestri, Fabio Aureli, Antonio Sturniolo

Research output: Contribution to journalArticle

Abstract

Objective/Background. To describe an uncommon, life-threatening condition such as angiosarcoma of a fistula for hemodialysis occurring in a transplant recipient affected by Lowe's syndrome. Summary. We present the case of a 56-year-old male kidney transplant recipient affected by Lowe's syndrome, also known as oculocerebrorenal syndrome, a rare X-linked disorder characterized by congenital cataracts, hypotonia, intellectual disability, and Fanconi-like renal tubular dysfunction, who was diagnosed with angiosarcoma of a functioning arteriovenous fistula for hemodialysis. Conclusion. Angiosarcoma is a rare soft tissue tumor, and only 22 cases of angiosarcoma of arteriovenous fistulae were described so far; although a correlation between Lowe's syndrome and a higher risk of tumor compared to the general population has not been described so far, the mechanisms of disease causation could be an interesting starting point for future studies on a possible connection between the two events.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalCASE REPORTS IN NEPHROLOGY
Volume2020
DOIs
Publication statusPublished - 2020

Keywords

  • Lowe's syndrome

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